Coxsackie and Adenovirus Receptor-Like Membrane Protein

An Ig superfamily transmembrane protein that localizes to junctional complexes that occur between ENDOTHELIAL CELLS and EPTHELIAL CELLS. The protein may play a role in cell-cell adhesion and is the primary site for the attachment of ADENOVIRUSES during infection.

Also Known As:

Adipocyte Adhesion Molecule; CAR (Coxsackie-Adenovirus Receptor); CAR-Like Membrane Protein; CXADR-Like Membrane Protein; Coxsackie-Adenovirus Receptor; Adhesion Molecule, Adipocyte; CAR Like Membrane Protein; CXADR Like Membrane Protein; Coxsackie Adenovirus Receptor; Coxsackie and Adenovirus Receptor Like Membrane Protein; Receptor, Coxsackie-Adenovirus

Networked: 138 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Curiel, David T: 14 articles (06/2008 - 03/2002)
2.	Hemminki, Akseli: 12 articles (04/2012 - 03/2002)
3.	Kanerva, Anna: 10 articles (04/2012 - 03/2002)
4.	Alvarez, Ronald D: 7 articles (06/2008 - 03/2002)
5.	Wang, Minghui: 7 articles (06/2008 - 09/2003)
6.	Curiel, D T: 7 articles (05/2008 - 03/2001)
7.	Kangasniemi, Lotta: 4 articles (04/2012 - 05/2006)
8.	Siegal, Gene P: 4 articles (06/2008 - 07/2004)
9.	Zhu, Zeng B: 4 articles (06/2008 - 07/2004)
10.	Rauen, Katherine A: 4 articles (09/2005 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "In vitro and in vivo studies demonstrate that Coxsackie adenovirus receptor (CAR) or foliate receptor (FR)-mediated uptake of FA-Ad-loaded PTX induced highly anti-tumor activity. " 09/14/2023 - "CXADR-Like Membrane Protein Regulates Colonic Epithelial Cell Proliferation and Prevents Tumor Growth." 01/01/2021 - "All three nanocomplexes (Ad/P5N5LG, Ad/P5N2LG-FA, and Ad/P5N5LG-FA) internalized into cancer cells through coxsackie adenovirus receptor-independent endocytic mechanism and the cell uptake was more efficient than naked Ad. " 05/12/2020 - "PTX treatment increased the cytoplasmic HuR relocalization in cancer cells, enhanced viral replication through elevated E1A expression, and upregulated CAR (Coxsackie-adenovirus receptor) required for viral uptake. " 11/01/2017 - "APP-complexed replication-incompetent Ad (dAd/APP) exhibited 12-fold higher transduction efficiency than naked dAd in coxsackie adenovirus receptor (CAR)-negative cancer cells. "
2.	Infections 05/01/2006 - "Most studies utilized adenovirus serotype 5 (Ad5) based vectors, which as adhesion molecules require the coxsackie adenovirus receptor (CAR) as a critical determinant for cellular infection. " 01/09/2019 - "However, MSCs are notoriously refractory to adenoviral infection, mainly because CAR (Coxsackie-Adenovirus Receptor) expression is absent or downregulated. " 12/01/2015 - "We also prepared replication-competent Ad5 that were activated with the same region but had the type 35 Ad-derived fiber-knob region (AdF35) to convert the major cellular receptor for Ad infection from the coxsackie adenovirus receptor to CD46 molecules. " 06/01/2015 - "Although replication-defective adenoviruses provide an attractive alternative for gene delivery, their use has been hampered by the limited susceptibility of murine leukocytes to adenoviral infection, due to insufficient expression of the human coxsackie/adenovirus receptor (CAR). " 06/01/2011 - "In this report, we investigated the role of the coxsackie-adenovirus-receptor (CAR) as a potential DAF co-receptor during E6 infection. "
3.	Adenoviridae Infections (Adenovirus Infections) 01/01/2001 - "Manipulation of the cytoplasmic and transmembrane domains alters cell surface levels of the coxsackie-adenovirus receptor and changes the efficiency of adenovirus infection." 10/01/2000 - "Many cell types, including lymphocytes, are refractory to adenovirus infection because they lack the Coxsackie/adenovirus receptor (CAR) needed for virus attachment. " 10/01/2000 - "Expression of a human coxsackie/adenovirus receptor transgene permits adenovirus infection of primary lymphocytes." 01/01/2005 - "Unfortunately, recent data suggest that the primary receptor, the coxsackie-adenovirus receptor (CAR) expression in tumors may be highly variable resulting in resistance to adenovirus infection. " 06/01/2005 - "This study engineered an Epstein-Barr virus-transformed B-lymphoblastoid cell line permissive to adenovirus infection and elucidated key roles for both the coxsackie-adenovirus receptor and alphavbeta5 integrin in mediating entry of adenoviruses into these cells. "
4.	Cicatrix (Scar) 03/01/2007 - "To test this hypothesis, we constructed a bi-specific adaptor protein containing the extracellular domain of the coxsackie-adenovirus receptor (CAR) and the full-length melanotransferrin (sCAR-MTf), and investigated its ability to re-direct Ad5 vectors to the MTf transcytosis pathway. " 06/01/2007 - "To block the natural hepatic tropism of adenovirus and to "retarget" the virus to CEA-expressing tumors, we used a bispecific adapter protein (sCAR-MFE), which fuses the ectodomain of the coxsackie/adenovirus receptor (sCAR) with a single-chain anti-CEA antibody (MFE-23). " 07/20/2004 - "This transcytosis is transferrin receptor (TfR)-mediated with use of a bifunctional adaptor, soluble coxsackie adenovirus receptor (sCAR)-Tf, and is both temperature and iron dependent. " 03/14/2017 - "In this work, Dicentrarchus labrax fucose binding lectin (DlFBL) and Haliotis discus discus sialic acid binding lectin (HddSBL) were genetically fused with soluble coxsackie-adenovirus receptor (sCAR), and produced through a bacterial expression system. " 06/01/2009 - "In the work described, a specific mannose-binding lectin, Pinellia pedatisecta agglutinin (PPA), was genetically fused with the extracellular domain of coxsackie-adenovirus receptor (CAR) to generate the soluble CAR (sCAR)-PPA fusion protein. "
5.	Urinary Bladder Neoplasms (Bladder Cancer) 07/01/2004 - "Studies on bladder cancer cell lines have shown that low adenoviral (Ad) infectivity is associated with low-level coxsackie adenovirus receptor (CAR) expression. " 07/01/2004 - "Histone deacetylase inhibitors upregulate expression of the coxsackie adenovirus receptor (CAR) preferentially in bladder cancer cells." 09/01/2002 - "Integrin alpha(v) and coxsackie adenovirus receptor expression in clinical bladder cancer." 10/15/2006 - "Etoposide also increased adenoviral infection via enhancement of coxsackie-adenovirus receptor expression on bladder cancer and normal cells. " 07/01/2006 - "Reverse transcriptase polymerase chain reaction analysis was used to determine expression patterns of BSP and Coxsackie adenovirus receptor, a receptor known to interact with adenovirus, on multiple lines of bladder cancer (253J, 253J B-V, RT4, transitional cell carcinoma, T24, UMUC3, and WH). "

Related Drugs and Biologics

1.	AD 5
2.	Proteins (Proteins, Gene)
3.	Integrin alphaV
4.	Protein Isoforms (Isoforms)
5.	Uroplakin III
6.	Cadherins (E-Cadherin)
7.	Messenger RNA (mRNA)
8.	Ligands
9.	Hormones (Hormone)
10.	integrin alphaVbeta5

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Castration