Junctional Adhesion Molecules

A family of membrane glycoproteins localized to TIGHT JUNCTIONS that contain two extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail of variable length.

Also Known As:

Networked: 89 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aurrand-Lions, Michel: 6 articles (10/2018 - 08/2009)
2.	Imhof, Beat A: 5 articles (01/2018 - 08/2009)
3.	Pichiorri, Flavia: 3 articles (06/2017 - 12/2014)
4.	Havran, Wendy L: 2 articles (10/2021 - 09/2010)
5.	Witherden, Deborah A: 2 articles (10/2021 - 09/2010)
6.	Xue, Fei: 2 articles (01/2021 - 01/2019)
7.	Yang, Jianmin: 2 articles (01/2021 - 01/2019)
8.	Lathia, Justin D: 2 articles (11/2020 - 01/2014)
9.	Naik, Ulhas P: 2 articles (11/2020 - 01/2014)
10.	Beiras-Fernandez, Andres: 2 articles (02/2020 - 02/2016)

Related Diseases

1.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/01/2018 - "Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis." 11/13/2009 - "However, it is down-regulated by inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, IL-17, interferon-gamma, IL-1beta, and IL-6 in vitro, and is also reduced in active multiple sclerosis (MS) lesions and in the inflamed spinal cord of experimental autoimmune encephalomyelitis, an animal model of MS. Furthermore, IL-25 restores the reduced expression of tight junction proteins, occludin, junction adhesion molecule, and claudin-5, induced by TNF-alpha in BCECs and consequently repairs TNF-alpha-induced blood-brain barrier (BBB) permeability. " 01/01/2021 - ": 22q11DS 22q11 deletion syndrome; ACKR1 atypical chemokine receptor 1; AD Alzheimer disease; AQP aquaporin; ATP adenosine triphosphate; Aβ amyloid β; BAC bacterial artificial chromosome; BBB blood-brain barrier; C/EBP-α CCAAT/enhancer-binding protein α; cAMP cyclic adenosine monophosphate (or 3',5'-cyclic adenosine monophosphate); CD cluster of differentiation; CNS central nervous system; DSRED discosoma red; EAE experimental autoimmune encephalomyelitis; ECV304 immortalized endothelial cell line established from the vein of an apparently normal human umbilical cord; EGFP enhanced green fluorescent protein; ESAM endothelial cell-selective adhesion molecule; GLUT-1 glucose transporter 1; GVB gut-vascular barrier; H2B histone H2B; HAPP human amyloid precursor protein; HEK human embryonic kidney; JACOP junction-associated coiled coil protein; JAM junctional adhesion molecules; LYVE1 lymphatic vessel endothelial hyaluronan receptor 1; MADCAM1 mucosal vascular addressin cell adhesion molecule 1; MAPK mitogen-activated protein kinase; MCAO middle cerebral artery occlusion; MMP metalloprotease; MS multiple sclerosis; MUPP multi-PDZ domain protein; PATJ PALS-1-associated tight junction protein; PDGFR-α platelet-derived growth factor receptor α polypeptide; PDGFR-β platelet-derived growth factor receptor β polypeptide; RHO rho-associated protein kinase; ROCK rho-associated, coiled-coil-containing protein kinase; RT-qPCR real time quantitative polymerase chain reactions; PDGFR-β soluble platelet-derived growth factor receptor, β polypeptide; T24 human urinary bladder carcinoma cells; TG2576 transgenic mice expressing the human amyloid precursor protein; TNF-α tumor necrosis factor α; WTwild-type; ZO zonula occludens."
2.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/2017 - "New treatment for non-Hodgkin B-cell lymphomas with a special focus on the impact of junctional adhesion molecules." 11/01/2016 - "Junctional adhesion molecule (JAM)-C is a member of the JAM family, expressed by a variety of different cell types, including human B lymphocytes and some B-cell lymphoma subtypes-in particular, mantle cell lymphoma (MCL). "
3.	Herpes Zoster 02/01/2013 - "Tissue-specific expression of occludin, zona occludens-1, and junction adhesion molecule A in the duodenum, ileum, colon, kidney, liver, lung, brain, and skeletal muscle of C57BL mice." 07/01/2010 - "This BBB dysfunction was associated with altered expression of tight junction proteins zona occuldens (ZO-1) and junctional adhesion molecule (JAM)-2. " 07/01/2023 - "The tight junctions (TJ) are multiprotein junctional complexes that consist of a number of members of the occludin, claudin, zona occludens, and junctional adhesion molecule families. " 10/01/2016 - "Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs." 11/01/2003 - "Polyamine depletion did not alter expression of tight junction proteins such as zona occludens (ZO)-1, ZO-2, and junctional adhesion molecule (JAM)-1. "
4.	Hypothermia 02/21/2020 - "This study investigates the effect of deep hypothermia and posterior rewarming on leukocyte-endothelial interactions and junctional adhesion molecules. " 02/25/2016 - "The role of hypothermia and the subsequent rewarming process on leukocyte-endothelial interactions and expression of junctional-adhesion-molecules is not clarified yet. " 02/25/2016 - "Influence of hypothermia and subsequent rewarming upon leukocyte-endothelial interactions and expression of Junctional-Adhesion-Molecules A and B."
5.	Critical Illness (Critically Ill) 10/01/2023 - "In an effort to better manage critically ill patients hospitalised in the intensive care unit (ICU) after experiencing multiple traumas, the present study aimed to assess whether plasma levels of intestinal epithelial cell barrier proteins, including occludin, claudin-1, junctional adhesion molecule (JAM-1), tricellulin and zonulin, could be used as novel biomarkers. "

Related Drugs and Biologics

1.	Occludin
2.	Proteins (Proteins, Gene)
3.	Claudin-1
4.	Tight Junction Proteins
5.	Claudins
6.	Messenger RNA (mRNA)
7.	Biomarkers (Surrogate Marker)
8.	cadherin 5
9.	MARVEL Domain Containing 2 Protein
10.	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)

Related Therapies and Procedures

1.	Rewarming
2.	Ligation
3.	Immunotherapy