Degenerin Sodium Channels

A family of mechanosensitive sodium channels found primarily in NEMATODES where they play a role in CELLULAR MECHANOTRANSDUCTION. Degenerin sodium channels are structurally-related to EPITHELIAL SODIUM CHANNELS and are named after the fact that loss of their activity results in cellular degeneration.

Also Known As:

Networked: 26 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Drummond, Heather A: 2 articles (01/2022 - 01/2022)
2.	Gouaux, Eric: 2 articles (02/2014 - 09/2007)
3.	Bartoszewski, Rafal: 2 articles (06/2011 - 09/2009)
4.	Bebok, Zsuzsanna: 2 articles (06/2011 - 09/2009)
5.	Benos, Dale J: 2 articles (06/2011 - 09/2009)
6.	Fuller, Catherine M: 2 articles (06/2011 - 09/2009)
7.	Kapoor, Niren: 2 articles (06/2011 - 09/2009)
8.	Granger, Joey P: 1 article (01/2022)
9.	Liu, Ruisheng: 1 article (01/2022)
10.	Lu, Yan: 1 article (01/2022)

Related Diseases

1.	Glioma (Gliomas) 09/04/2009 - "We also found a significant inhibition of D54-MG cell migration after ASIC1, alphaENaC, or gammaENaC knockdown, consistent with the hypothesis that ENaC/Degenerin subunits play an important role in glioma cell biology." 09/04/2009 - "High grade gliomas such as glioblastoma multiforme express multiple members of the epithelial sodium channel (ENaC)/Degenerin family, characteristically displaying a basally active amiloride-sensitive cation current not seen in normal human astrocytes or lower grade gliomas. " 12/01/2013 - "Recent studies have implicated the acid-sensing ion channel 1 (ASIC1), a proton-gated cation channel that belongs to the epithelial sodium channel (ENaC)/Degenerin family, plays an important role in glioma cell migration. "
2.	Pre-Eclampsia (Preeclampsia) 01/01/2022 - "This brief review links studies showing the effect of proinflammatory cytokines on degenerin expression and CBF autoregulation to the pathological cerebral consequences of preeclampsia." 01/01/2022 - "Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia?"
3.	Pain (Aches) 12/01/2013 - "Epithelial Na(+) channel (ENaC)/degenerin family members are involved in mechanosensation, blood pressure control, pain sensation, and the expression of fear. " 08/01/1998 - "The emerging epithelial Na channel/degenerin family of sodium channels is rapidly expanding, in particular with new members expressed in mammalian neurons and potentially involved in pain transmission. " 01/16/2001 - "We propose that ASIC3, a member of the degenerin channel (of Caenorhabditis elegans)/epithelial sodium channel family of ion channels, is the sensor of myocardial acidity that triggers cardiac pain, and that it might be a useful pharmaceutical target for treating angina." 09/01/1998 - "We propose a novel extracellular signal transduction pathway controlling ionic channels of the ENaC gene family that include genes involved in mechanotransduction (degenerins), in peptide-gated channels involved in neurotransmission (FaNaCh), in proton-gated channels involved in pH sensing (ASIC) or pain sensation (DRASIC)." 09/20/2007 - "Acid-sensing ion channels (ASICs) are voltage-independent, proton-activated receptors that belong to the epithelial sodium channel/degenerin family of ion channels and are implicated in perception of pain, ischaemic stroke, mechanosensation, learning and memory. "
4.	Pathologic Processes 03/15/2011 - "As an H(+)-gated subgroup of the degenerin/epithelial Na(+) channel family, acid-sensing ion channels (ASICs) were reported to be involved in various physiological and pathological processes in neurons. " 12/29/2017 - "The degenerin/epithelial sodium channel (DEG/ENaC) superfamily of ion channels contains subfamilies with diverse functions that are fundamental to many physiological and pathological processes, ranging from synaptic transmission to epileptogenesis. " 04/01/2019 - "Acid‑sensing ion channel 1a (ASIC1a), member of the degenerin/epithelial sodium channel protein superfamily, serves a critical role in various physiological and pathological processes. "
5.	Neoplasms (Cancer) 10/01/2000 - "A novel strategy for cancer therapy by mutated mammalian degenerin gene transfer." 01/01/2011 - "voltage-gated K(+), Na(+), Ca(2+) channels, TRP channels, and epithelial Na(+)/degenerin family of ion channels, are involved in the growth/proliferation, migration and/or invasion of cancer cells. " 06/01/2011 - "These tumors express multiple members of the epithelial sodium channel (ENaC)/degenerin (Deg) family and are associated with a basally active amiloride-sensitive cation current. "

Related Drugs and Biologics

1.	Epithelial Sodium Channels
2.	Acid Sensing Ion Channels
3.	Protons (Proton)
4.	Cations
5.	Cytokines
6.	Ion Channels (Ion Channel)
7.	Amiloride (Midamor)
8.	Peptides (Polypeptides)
9.	Proteins (Proteins, Gene)
10.	Caspases

Related Therapies and Procedures

1.	Therapeutics