Mechanical Thrombolysis

Procedures to cause the disintegration of THROMBI by physical interventions.

Also Known As:

Mechanical Clot Disruption; Clot Disruption, Mechanical; Clot Disruptions, Mechanical; Disruption, Mechanical Clot; Disruptions, Mechanical Clot; Mechanical Clot Disruptions; Thrombolysis, Mechanical

Networked: 145 relevant articles (15 outcomes, 14 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Acampa, Maurizio: 3 articles (01/2022 - 01/2014)
2.	Guideri, Francesca: 3 articles (01/2022 - 01/2014)
3.	Martini, Giuseppe: 3 articles (01/2022 - 01/2014)
4.	Tassi, Rossana: 3 articles (01/2022 - 01/2014)
5.	Schroth, Gerhard: 3 articles (04/2012 - 03/2009)
6.	Bracco, Sandra: 2 articles (01/2022 - 01/2021)
7.	Domenichelli, Carlo: 2 articles (01/2022 - 01/2021)
8.	Lazzerini, Pietro Enea: 2 articles (01/2022 - 01/2021)
9.	Kirton, Adam: 2 articles (11/2021 - 09/2003)
10.	Alexandrov, Andrei V: 2 articles (01/2021 - 02/2005)

Related Diseases

1.	Ischemic Stroke 03/01/2009 - "No controlled, randomized trial has investigated whether intravenous, intra-arterial (IAT), or mechanical thrombolysis is beneficial in children with ischemic stroke. " 01/01/2002 - "Recent advancements in the evaluation and treatment of acute ischemic stroke, including intra-arterial thrombolysis, mechanical thrombolysis, and combination therapies, hold significant promise for a larger proportion of patients. " 04/01/2008 - "Mechanical thrombolysis may effectively enhance the efficacy of thrombolysis for hyperacute ischemic stroke patients. " 01/01/2006 - "Mechanical thrombolysis in ischemic stroke attributable to basilar artery occlusion as first-line treatment." 01/01/2021 - "We enrolled all patients admitted to Siena-Hospital for ischemic stroke and submitted them to acute treatments (intravenous and/or mechanical thrombolysis) between February 21st and May 18th, 2020 (study group, n:38) and compared the results with ischemic strokes acutely treated in a similar period in 2019 (control group, n:39). "
2.	Stroke (Strokes) 01/01/2021 - "A proactive clinical approach to stroke care improved functional outcomes with implementation of specialized in-hospital stroke units, urgently delivered systemic thrombolysis, mechanical thrombectomy and most recently with mobile stroke units deployed in the field. " 10/01/2012 - "All patients reported a significant improvement in symptoms (mean baseline NIHSS 19.6±5.6; mean postprocedural NIHSS, 7.8±5.5 p<0.0001) Our preliminary experience with the Penumbra mechanical thrombolysis system confirms previously reported results showing the efficacy and safety of the device in treating acute stroke caused by the occlusion of large intracranial vessels." 02/01/2005 - "This study evaluated the safety and efficacy of aggressive mechanical clot disruption (AMCD) in acute stroke patients with persisting middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion after thrombolytic therapy. " 03/01/2009 - "We searched in MEDLINE and EMBASE for studies that reported on treatment of childhood stroke with intravenous thrombolysis, IAT, or mechanical thrombolysis in the presence of occlusion of the basilar artery, sphenoidal, or insular middle cerebral artery. " 01/01/2021 - "These include neuroimaging, acute stroke unit care, management of blood pressure, reperfusion therapy including intravenous thrombolysis, mechanical thrombectomy and decompressive hemicraniectomy for malignant stroke syndrome. "
3.	Thrombosis (Thrombus) 03/01/2002 - "The aim of our study was to compare the efficacy of three devices for mechanical thrombolysis in removing the thrombus from thrombosed haemodialysis access grafts and to determine the initial technical and clinical success, complication rates of each device, and graft patency after the procedure. " 12/25/2018 - "Among them, 94 cases were treated with AngioJet mechanical thrombolysis or additional thrombolysis for residual thrombus (PMT group) and 76 cases were treated with catheter-directed thrombolysis(CDT group). " 01/01/2017 - "Mechanical thrombolysis as an adjunct therapy to management of portal vein thrombosis following Radio Frequency Ablation." 10/01/2014 - "A mechanical thrombolysis technique can be used to dissolve thrombus effectively from thrombosed implanted CVP on an outpatient basis." 10/01/2014 - "Our mechanical thrombolysis technique was performed to fragment thrombus in the port chamber by whirling the floppy tip of 0.018-inch hair-wire. "
4.	Venous Thrombosis (Deep-Vein Thrombosis) 11/01/2020 - "The safety and efficacy of pharmaco-mechanical thrombolysis in lower-extremity deep venous thrombosis." 03/01/2021 - "In this study, we aimed to evaluate the efficiency of rotational thrombectomy device in pharmaco-mechanical thrombolysis for symptomatic acute ilio-femoral deep vein thrombosis. " 03/01/2021 - "In conclusion, Pharmaco-mechanical thrombolysis with Cleaner thrombectomy device is a safe and beneficial method for the treatment of acute iliofemoral deep vein thrombosis. " 03/01/2021 - "Between August 2013 and May 2018,82 patients with acute deep vein thrombosis comprising the iliofemoral segment whom underwent Pharmaco-mechanical thrombolysis were evaluated retrospectively. " 07/01/2017 - "We report a case of early detection of pancreatic graft venous thrombosis that was treated successfully by catheter-directed thrombolysis mechanical thrombectomy, percutaneous transluminal angioplasty, and stenting of portal vein."
5.	Intracranial Sinus Thrombosis (Sinus Thrombosis) 07/01/2014 - "Endovascular treatment of cerebral venous sinus thrombosis (CVST) includes pharmacological and mechanical thrombolysis. " 07/01/2009 - "The authors report a unique case of a patient successfully treated with endovascular mechanical thrombolysis using balloon angioplasty for clinically significant posttraumatic venous sinus thrombosis and review the reported treatments for cerebral venous sinus occlusive disease. " 12/01/2005 - "Mechanical thrombolysis for treatment of acute sinus thrombosis--case report." 08/01/2004 - "Two patients with dural sinus thrombosis and rapidly deteriorating levels of consciousness underwent unsuccessful attempts at mechanical thrombolysis via the usual transfemoral route. " 03/01/2001 - "Five patients with dural sinus thrombosis were treated with a combination of pharmacological and mechanical thrombolysis with the 5-French Angiolet rheolytic catheter (Possis Medical, Minneapolis, MN) and balloon catheters. "

Related Drugs and Biologics

1.	Urokinase-Type Plasminogen Activator (Urokinase)
2.	Tissue Plasminogen Activator (Alteplase)
3.	Tirofiban (Aggrastat)
4.	Fibrinolytic Agents (Antithrombotic Agents)
5.	Heparin (Liquaemin)
6.	Glycoproteins (Glycoprotein)
7.	Abciximab (ReoPro)
8.	Elastomers (Elastomer)
9.	Platelet Membrane Glycoproteins
10.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)

Related Therapies and Procedures

1.	Therapeutics
2.	Thrombolytic Therapy
3.	Thrombectomy
4.	Catheters
5.	Mechanical Thrombolysis