External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
Also Known As:
HIV Envelope Glycoprotein gp120; gp120 Envelope Glycoprotein, HIV; HTLV III gp120; gp120, HTLV-III; Envelope Glycoprotein gp120, HIV; HTLV-III gp120; env Protein gp120, HIV; gp120(HIV)