Disulfiram (Antabuse)
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Also Known As:
Antabuse; Antabus; Alcophobin; Anticol; Bis(diethylthiocarbamoyl) Disulfide; Dicupral; Esperal; Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2; Teturam; Disulfide, Tetraethylthiuram; Tetraethylthiuram Disulfide; Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-
Networked: 1619
relevant articles (115 outcomes,
205 trials/studies)
Relationship Network
Drug Context: Research Results
Experts
1. | Wang, Weiguang:
16 articles
(01/2022 - 04/2003)
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2. | Kosten, Thomas R:
14 articles
(01/2021 - 04/2002)
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3. | Ito, Yoshimasa:
12 articles
(01/2015 - 02/2003)
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4. | Dou, Q Ping:
10 articles
(01/2019 - 11/2006)
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5. | Nich, Charla:
10 articles
(03/2016 - 03/2004)
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6. | Nagai, Noriaki:
10 articles
(01/2015 - 12/2007)
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7. | Tang, Xing:
9 articles
(06/2022 - 10/2013)
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8. | Kast, Richard E:
9 articles
(05/2022 - 02/2009)
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9. | Petrakis, Ismene L:
9 articles
(11/2017 - 03/2004)
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10. | Mutschler, Jochen:
9 articles
(10/2016 - 01/2008)
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