Acamprosate (Campral)

Structural analog of taurine that is used for the prevention of relapse in individuals with ALCOHOLISM.

Also Known As:

Campral; Acamprosate Calcium; Acamprostate; Aotal; Calcium Acetyl Homotaurinate; Calcium Acetylhomotaurinate; Calcium Acetylhomotaurine; Campral EC; N-Acetylhomotaurine; N-Acetylhomotaurine, Calcium (2:1) Salt; N-Acetylhomotaurine, Magnesium (2:1) Salt; N-Acetylhomotaurine, Monolithium Salt; N-Acetylhomotaurine, Monopotassium Salt; N-Acetylhomotaurine, Monosodium Salt; N-Acetylhomotaurine, Zinc (2:1) Salt; Regtect; Sodium Acetylhomotaurine; Zulex; Acetyl Homotaurinate, Calcium; Acetylhomotaurinate, Calcium; Acetylhomotaurine, Calcium; Acetylhomotaurine, Sodium; N Acetylhomotaurine; N Acetylhomotaurine, Monolithium Salt; N Acetylhomotaurine, Monopotassium Salt; N Acetylhomotaurine, Monosodium Salt; 1-Propanesulfonic acid, 3-(acetylamino)-

Networked: 378 relevant articles (63 outcomes, 96 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Alkanesulfonic Acids
        Taurine: 3452
        Acamprosate: 378
        ribavirin drug combination acamprosate: 6
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfonic Acids: 1605
      - Alkanesulfonic Acids
        Taurine: 3452
        Acamprosate: 378
        ribavirin drug combination acamprosate: 6

Experts

1.	Lehert, Philippe: 14 articles (09/2018 - 10/2002)
2.	Mason, Barbara J: 13 articles (02/2015 - 10/2002)
3.	Kiefer, Falk: 10 articles (11/2021 - 01/2003)
4.	Mann, Karl: 7 articles (11/2021 - 01/2004)
5.	Soyka, Michael: 7 articles (10/2016 - 01/2002)
6.	Karpyak, Victor M: 6 articles (01/2022 - 03/2014)
7.	Erickson, Craig A: 6 articles (01/2017 - 11/2010)
8.	Choi, Doo-Sup: 5 articles (01/2022 - 02/2011)
9.	O'Malley, Stephanie S: 5 articles (11/2021 - 06/2003)
10.	Teesson, Maree: 5 articles (10/2021 - 10/2006)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 02/01/2015 - "To undertake a double-blind, randomized, placebo-controlled trial to examine the efficacy of acamprosate in maintaining complete abstinence in Japanese patients with alcohol dependence. " 01/01/2008 - "Using a more stringent definition of abstinence, re-analysis of the rate of complete abstinence, percent days abstinent, and the time to first drink confirmed the original findings for the efficacy of acamprosate in the treatment of alcohol dependence. " 03/01/2005 - "Acamprosate is a proven effective intervention in the treatment of alcohol dependence. " 11/01/2014 - "Herein, the authors review the preclinical studies which have assessed the efficacy of acamprosate in various animal models of alcohol dependence and discuss the disparate findings from the major clinical trials. " 02/01/2015 - "Acamprosate is superior to placebo in maintaining abstinence in Japanese patients with alcohol dependence. "
2.	Tinnitus 11/01/2020 - "For those subjects who were receiving acamprosate, a significant reduction was observed in tinnitus handicap inventory (P = .006), tinnitus questionnaire scores (P = .007), and the visual analog scores (P = .007) compared to the placebo group. " 01/01/2012 - "(1)To study the effectiveness of acamprosate in providing subjective relief and objective improvement in patients having tinnitus of sensorineural origin. " 11/01/2020 - "The study results indicated a subjective relief of tinnitus as well as some degree of the electrophysiological improvement at the level of the cochlear and the distal portion of the auditory nerve among the subjects who received the acamprosate. " 11/01/2020 - "After performing psycho-acoustic, psychometric and electrophysiological evaluations, all studied tinnitus subjects were randomly divided into two groups of acamprosate and placebo. " 11/01/2020 - "Thus, we aimed to evaluate the efficacy and safety of acamprosate in the treatment of tinnitus. "
3.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 08/01/2018 - "Acamprosate significantly ameliorates the pathological features of experimental autoimmune encephalomyelitis due to its anti-inflammatory effect. " 02/01/2012 - "Acamprosate modulates experimental autoimmune encephalomyelitis." 02/01/2012 - "This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). "
4.	Schizophrenia (Dementia Praecox) 01/01/2011 - "Acamprosate was not more effective than placebo in reducing drinking or symptoms of schizophrenia. " 01/01/2011 - "No study to date has examined the efficacy of acamprosate in patients with alcohol dependence and comorbid schizophrenia. " 07/01/2011 - "Effects of acamprosate on cognition in a treatment study of patients with schizophrenia spectrum disorders and comorbid alcohol dependence." 01/01/2008 - "Unfortunately no studies are available using acamprosate in patients with schizophrenia and comorbid alcoholism. " 07/01/2011 - "Outpatients with schizophrenia spectrum disorders and alcohol dependence (n = 23) were randomized (double-blind) to either acamprosate or placebo treatment for 12 weeks. "
5.	Sleep Initiation and Maintenance Disorders (Insomnia) 09/01/2018 - "Based on a large clinical trial database, the aim of the present study is to assess the efficacy of acamprosate in reducing insomnia, and if indeed it does reduce insomnia, to better understand its action mechanism. " 09/01/2018 - "The aim of the study is to confirm the efficacy of acamprosate to reduce insomnia using an individual patient data meta-analysis. " 09/01/2018 - "An individual patient data meta-analysis selected all the randomized trials of acamprosate in which insomnia was documented. " 09/01/2018 - "By using a univariate mediation model, we found that the mediating effect of abstinence on insomnia accounted for 55.7% of the overall effect of acamprosate on insomnia reduction. " 09/01/2018 - "After a 6-month follow-up, the mean insomnia decrease over baseline was -26% and -45% for the placebo and acamprosate groups, respectively (P < 0.001). "

Related Drugs and Biologics

1.	Naltrexone (ReVia)
2.	Disulfiram (Antabuse)
3.	Baclofen
4.	nalmefene (Revex)
5.	Topiramate (Topamax)
6.	Narcotic Antagonists (Opioid Antagonists)
7.	tramiprosate
8.	Calcium
9.	Gabapentin (Neurontin)
10.	Serotonin Agents

Related Therapies and Procedures

1.	Secondary Prevention
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Aftercare (After-Treatment)
5.	Tobacco Use Cessation Devices