Severe Fever with Thrombocytopenia Syndrome

A tick-borne infection with SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME BUNYAVIRUS of the genus Phlebovirus. It is associated with fever, THROMBOCYTOPENIA; LEUKOCYTOPENIA, and multiorgan dysfunction. It is found in parts of Asia including China, Japan, Korea and Vietnam and can be transmitted from infected domestic animals and humans.

Also Known As:

Networked: 264 relevant articles (5 outcomes, 21 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Virus Diseases (Viral Diseases)
3.	Fever (Fevers)
4.	COVID-19
5.	Disease Progression

Experts

1.	Saijo, Masayuki: 25 articles (03/2022 - 01/2014)
2.	Shimojima, Masayuki: 21 articles (03/2022 - 01/2014)
3.	Deng, Fei: 12 articles (02/2022 - 06/2013)
4.	Tani, Hideki: 12 articles (01/2021 - 01/2014)
5.	Taniguchi, Satoshi: 12 articles (01/2021 - 01/2014)
6.	Liu, Wei: 11 articles (09/2022 - 11/2013)
7.	Fukushi, Shuetsu: 11 articles (01/2021 - 01/2014)
8.	Liang, Mifang: 11 articles (05/2019 - 08/2012)
9.	Li, Chuan: 10 articles (05/2019 - 08/2012)
10.	Li, Dexin: 10 articles (05/2019 - 08/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Severe Fever with Thrombocytopenia Syndrome:

1.	Ribavirin (Virazole)FDA LinkGeneric 01/01/2021 - "This study described the clinical features, risk factors, factors affecting the outcome of this disease, and ribavirin therapeutic efficacy for severe fever with thrombocytopenia syndrome (SFTS) patients in Hefei. " 01/01/2021 - "Severe fever with thrombocytopenia syndrome in Hefei: Clinical features, risk factors, and ribavirin therapeutic efficacy." 11/02/2015 - "The combined usage of one of type-I/II IFNs with ribavirin drastically reduced SFTS virus infection and therefore may be useful in the treatment of SFTS." 01/01/2014 - "Effects of ribavirin on severe fever with thrombocytopenia syndrome virus in vitro." 07/01/2015 - "Common adverse events associated with ribavirin therapy for Severe Fever with Thrombocytopenia Syndrome."
2.	favipiravirIBA 01/01/2021 - "A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe fever with thrombocytopenia syndrome." 10/01/2021 - "Clinical efficacy and safety evaluation of favipiravir in treating patients with severe fever with thrombocytopenia syndrome." 01/01/2016 - "Efficacy of T-705 (Favipiravir) in the Treatment of Infections with Lethal Severe Fever with Thrombocytopenia Syndrome Virus." 02/01/2017 - "Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir." 01/01/2020 - "In addition to influenza, favipiravir has a broad spectrum of anti-RNA virus activities in vitro and efficacies in animal models with lethal RNA viruses and has been used for treatment of human infection with life-threatening Ebola virus, Lassa virus, rabies, and severe fever with thrombocytopenia syndrome. "
3.	VaccinesIBA 01/01/2019 - "Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus." 06/01/2023 - "Severe fever with thrombocytopenia syndrome (SFTS) has no vaccine or treatment and an extremely high fatality rate. " 01/01/2023 - "Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen for which approved therapeutic drugs or vaccines are not available. " 10/01/2021 - "LC16m8 is a vaccine candidate for severe fever with thrombocytopenia syndrome. " 06/01/2021 - "A rabies virus vectored severe fever with thrombocytopenia syndrome (SFTS) bivalent candidate vaccine confers protective immune responses in mice."
4.	mRNA VaccinesIBA 10/31/2023 - "mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice." 10/31/2023 - "We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. "
5.	Proteins (Proteins, Gene)FDA Link 04/01/2014 - "In this study, we report that the nonstructural protein NSs of the newly described severe fever with thrombocytopenia syndrome virus (SFTSV) is a potent inhibitor of IFN responses. " 10/26/2023 - "We then demonstrated that L protein of severe fever with thrombocytopenia syndrome virus (SFTSV) could interact with mRNAs of WNT-CTNNB1 signaling pathway-related gene, thus affecting WNT-CTNNB1 signaling pathway through its cap-snatching activity. " 04/11/2023 - "Correction to 'structural and functional characterization of the Severe fever with thrombocytopenia syndrome virus L protein'." 01/01/2023 - "Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein." 01/01/2022 - "Sequence alignment of the 13 BCEs against homologous proteins from 10 closely related strains of severe fever with thrombocytopenia syndrome virus from different geographical regions revealed that the amino acid sequences of EGc4, EGc5, EGc8, EGc11, and EGc12 were highly conserved, with 100% similarity. "
6.	AntibodiesIBA 03/01/2019 - "In this study, an up-converting phosphor technology-based lateral-flow (UPT-LF) assay was developed to detect severe fever with thrombocytopenia syndrome virus (SFTSV) total antibodies rapidly and specifically. " 01/01/2018 - "The purpose of this study was to investigate the seroprevalence of antibodies against severe fever with thrombocytopenia syndrome virus (SFTSV) in shelter dogs in the Republic of Korea (ROK) using an indirect immunofluorescence assay and virus neutralization test. " 01/01/2022 - "Analysis of cross neutralizing activity of antibodies from sera of severe fever with thrombocytopenia syndrome patients to deal with different genotype strains." 01/01/2021 - "Time Course of Severe Fever With Thrombocytopenia Syndrome Virus and Antibodies in Patients by Long-Term Follow-Up Study, China." 03/01/2019 - "Rapid detection of severe fever with thrombocytopenia syndrome virus (SFTSV) total antibodies by up-converting phosphor technology-based lateral-flow assay."
7.	NucleoproteinsIBA 05/01/2014 - "This study aims to investigate whether the nucleoprotein (NP) of severe fever with thrombocytopenia syndrome virus (SFTSV) can impact the cellular immunity of host cells. " 01/01/2023 - "Non-Structural Protein-W61 as a Novel Target in Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV): An In-Vitro and In-Silico Study on Protein-Protein Interactions with Nucleoprotein and Viral Replication." 09/01/2023 - "Developing and characterizing monoclonal antibodies of Guertu bandavirus nucleoprotein for developing methods of Guertu bandavirus and severe fever with thrombocytopenia syndrome virus detection." 01/01/2023 - "The non-structural protein (NSs) and nucleoprotein (NP) of the severe fever with thrombocytopenia syndrome virus (SFTSV) encoded by the S segment are crucial for viral pathogenesis. " 01/01/2021 - "Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets."
8.	CytokinesIBA 01/01/2021 - "Changes in peripheral blood cytokines in patients with severe fever with thrombocytopenia syndrome." 01/01/2018 - "Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome." 01/01/2017 - "Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome." 03/01/2016 - "Serial Changes of Serum Cytokine in a Pediatric Patient with Severe Fever with Thrombocytopenia Syndrome." 01/01/2023 - "Severe fever with thrombocytopenia syndrome virus (SFTSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause the hyperproduction of inflammatory cytokines, which have pathological effects in patient including severe or fatal cytokine storms. "
9.	EnzymesIBA 11/01/2023 - "The increased pancreatic enzymes have recently been reported in patients with severe fever with thrombocytopenia syndrome (SFTS). " 11/01/2023 - "Prevalence and clinical characteristics of increased pancreatic enzymes in patients with severe fever with thrombocytopenia syndrome." 01/01/2022 - "Bunyavirus causes severe fever with thrombocytopenia syndrome (SFTS), with signs and symptoms including high fever, vomiting, diarrhea, thrombocytopenia (low platelet count), leukopenia (low white blood cell count), elevated liver enzyme levels, multiple organ failure, and has a 6%-30% case-fatality rate. " 03/30/2017 - "A serological study of severe fever with thrombocytopenia syndrome using a virus neutralization test and competitive enzyme-linked immunosorbent assay." 01/01/2018 - "Evaluation of two different enzyme-linked immunosorbent assay for severe fever with thrombocytopenia syndrome virus diagnosis."
10.	Immunoglobulin M (IgM)IBA 10/17/2022 - "Serological Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and IgM Positivity Were Identified in Healthy Residents in Vietnam." 06/02/2020 - "AuNP-LF assay showed outstanding selectivity in the detection of IgM against the SARS-CoV-2 virus with no interference from other viruses such as severe fever with thrombocytopenia syndrome virus (SFTSV) and dengue virus (DFV). " 04/01/2019 - "Nucleocapsid protein-specific IgM antibody responses in the disease progression of severe fever with thrombocytopenia syndrome." 07/01/2022 - "The MAbs against rSFTSV-N protein offer new tools for SFTSV studies and our newly developed MAb-based IgG and IgM capture ELISA systems would offer safe and useful tools for diagnosis of SFTS virus infections and epidemiological investigations." 01/01/2021 - "Methods: The levels of SFTSV, virus-specific immunoglobulin M (IgM), immunoglobulin G (IgG) titers, and cytokines in 37 patients with severe fever with thrombocytopenia syndrome (SFTS) were measured dynamically by real-time PCR and ELISA during the disease course; IgG titers were followed up in 53 cases. "

Therapies and Procedures

1.	Therapeutics 10/01/2021 - "Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality, however with no effective therapy available. " 01/01/2016 - "Use of Plasma Therapy for Severe Fever with Thrombocytopenia Syndrome Encephalopathy." 08/01/2023 - "Corticosteroid Therapy for Patients With Severe Fever With Thrombocytopenia Syndrome: A Nationwide Propensity Score-Matched Study in Japan." 05/01/2023 - "Steroid pulse therapy for severe fever with thrombocytopenia syndrome patients may not improve prognosis: Retrospective analysis with overlap weighting using a national inpatient database." 04/26/2023 - "Currently, there are no commercial vaccines or therapeutics against severe fever with thrombocytopenia syndrome (SFTS) virus. "
2.	Drug Therapy (Chemotherapy) 01/01/2023 - "A new model for predicting the outcome and effectiveness of drug therapy in patients with severe fever with thrombocytopenia syndrome: A multicenter Chinese study." 01/01/2023 - "There are a few models for predicting the outcomes of patients with severe fever with thrombocytopenia syndrome (SFTS) based on single-center data, but clinicians need more reliable models based on multicenter data to predict the clinical outcomes and effectiveness of drug therapy. "
3.	Oral Administration 01/01/2018 - "Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: Dose-efficacy studies upon oral administration."
4.	Plasma Exchange 01/15/2022 - "Plasma Exchange Did Not Reduce Viral Load in a Recovered Case of Severe Fever with Thrombocytopenia Syndrome." 07/01/2019 - "Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome." 07/01/2017 - "Effect of Early Plasma Exchange on Survival in Patients with Severe Fever with Thrombocytopenia Syndrome: A Multicenter Study." 12/01/2018 - "We describe the case of a patient with severe fever with thrombocytopenia syndrome (SFTS) complicated by SFTS-associated encephalopathy who was successfully treated with 4-day plasma exchange followed by two-time convalescent plasma therapy. " 01/01/2014 - "Plasma exchange and ribavirin for rapidly progressive severe fever with thrombocytopenia syndrome."
5.	Extracorporeal Membrane Oxygenation 05/01/2023 - "Few cases of acute respiratory distress syndrome (ARDS) in severe fever with thrombocytopenia syndrome (SFTS) have been treated with venovenous extracorporeal membrane oxygenation (VV-ECMO), and its role remains unclear. " 05/01/2023 - "Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome Due to Severe Fever With Thrombocytopenia Syndrome." 08/11/2021 - "Veno-arterial extracorporeal membrane oxygenation for severe fever with thrombocytopenia syndrome with fulminant myocarditis: a case report."