Felbamate (Felbatol)

A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.

Also Known As:

Felbatol; (3-Carbamoyloxy-2-phenyl-propyl) carbamate; 2-Phenyl-1,3-propanediol dicarbamate; ADD-03055; Felbamyl; Taloxa; W-554; 2 Phenyl 1,3 propanediol dicarbamate; ADD 03055; ADD03055; W 554; W554; 1,3-Propanediol, 2-phenyl-, dicarbamate

Networked: 286 relevant articles (66 outcomes, 53 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - Phenylcarbamates: 7
        Felbamate: 286
- Alcohols: 595
  - Glycols: 38
    - Propylene Glycols: 2
      - Felbamate: 286

Experts

1.	Shi, Li Li: 4 articles (01/2019 - 01/2011)
2.	Wielosz, Marian: 4 articles (01/2011 - 07/2003)
3.	Czuczwar, S J: 4 articles (05/2004 - 01/2000)
4.	Sofia, R Duane: 4 articles (11/2002 - 01/2002)
5.	Dong, JianCheng: 3 articles (01/2019 - 07/2014)
6.	Geng, JinSong: 3 articles (01/2019 - 07/2014)
7.	Faught, Edward: 3 articles (10/2018 - 10/2006)
8.	Wu, Taixiang: 3 articles (01/2017 - 01/2011)
9.	Czuczwar, Stanislaw J: 3 articles (03/2005 - 08/2004)
10.	Luszczki, Jarogniew J: 3 articles (03/2005 - 08/2004)

Related Diseases

1.	Seizures (Absence Seizure) 01/01/1993 - "There were no significant differences in the frequency of seizures occurring during video monitoring, but there was a significant reduction (P = 0.017) in the number of tonic-clonic seizures during the maintenance period in the felbamate group. " 10/01/2006 - "The past 10 years of clinical experience have demonstrated that when used in accordance with existing recommendations and close clinical monitoring, felbamate is an effective treatment for some patients with seizures refractory to other AEDs. " 07/01/1994 - "Felbamate may also be safe and effective in patients with generalized, absence, atypical absence, juvenile myoclonic, infantile, and gelastic seizures. " 07/01/2022 - "Felbamate is an anti-seizure drug with established pharmacokinetic and safety data for dogs, but little published evidence of efficacy for managing generalized seizures in this species. " 03/01/1995 - "Efficacy of felbamate monotherapy in patients undergoing presurgical evaluation of partial seizures."
2.	Lennox Gastaut Syndrome 01/01/1993 - "Felbamate is beneficial in patients with the Lennox-Gastaut syndrome." 01/01/1993 - "We studied the efficacy of felbamate in 73 patients ranging in age from 4 to 36 years who had the Lennox-Gastaut syndrome. " 03/01/1997 - "Felbamate was also the first drug to be tested in a placebo-controlled trial in children with the Lennox-Gastaut syndrome. " 01/01/1993 - "Felbamate in the treatment of Lennox-Gastaut syndrome: results of a 12-month open-label study following a randomized clinical trial." 01/01/2001 - "Felbamate remains indicated as third line drug in refractory Lennox-Gastaut syndrome provided blood parameters are controlled. "
3.	Epilepsy (Aura) 03/01/2016 - "This single center analysis retrospectively evaluated the safety and efficacy of felbamate in a cohort of children, adolescents, and adults with epilepsy. " 06/01/2010 - "Efficacy of felbamate in the treatment of intractable pediatric epilepsy." 07/01/2022 - "These results warrant a more controlled, prospective investigation into felbamate as a therapeutic agent for canine epilepsy." 01/01/2022 - "To evaluate the efficacy and tolerability of felbamate versus placebo when used as an add-on treatment for people with drug-resistant focal-onset epilepsy. " 01/01/2022 - "We retrospectively reviewed the medical files of all patients who were treated with felbamate in a tertiary pediatric epilepsy clinic between 2009-2021. "
4.	Infantile Spasms (West Syndrome) 03/01/1995 - "Controlled studies are needed to firmly establish that felbamate is both safe and effective for the treatment of infantile spasms. " 01/01/2020 - "The effectiveness of felbamate for drug-resistant infantile spasms." 01/01/2020 - "To analyse the effects of felbamate in refractory infantile spasms/West syndrome. " 01/01/2020 - "Felbamate for infantile spasms syndrome resistant to first-line treatments." 10/01/1997 - "Felbamate for refractory infantile spasms."
5.	Drug Resistant Epilepsy 11/01/1991 - "This trial indicates that felbamate is safe and effective in the treatment of comedicated patients with severely refractory epilepsy." 06/01/2010 - "This retrospective study evaluated the efficacy of felbamate in a pediatric population with intractable epilepsy. " 03/01/1997 - "[Felbamate: a long-term study in subjects with refractory epilepsy]." 01/01/2022 - "Concerns regarding felbamate adverse effects restrict its widespread use in children with drug-resistant epilepsy. " 11/01/2014 - "Based on its efficacy and safety data, earlier initiation of felbamate is recommended in children with refractory epilepsy."

Related Drugs and Biologics

1.	Lamotrigine (Lamictal)
2.	Anticonvulsants (Antiepileptic Drugs)
3.	Topiramate (Topamax)
4.	Vigabatrin
5.	Tiagabine (Gabitril)
6.	Oxcarbazepine (Trileptal)
7.	rufinamide
8.	Gabapentin (Neurontin)
9.	Zonisamide (Zonegran)
10.	Felbamate (Felbatol)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Ketogenic Diet
4.	Ligation
5.	Polypharmacy