Zonisamide (Zonegran)

A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.

Also Known As:

Networked: 787 relevant articles (164 outcomes, 200 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Murata, Miho: 14 articles (01/2022 - 01/2007)
2.	Marson, Anthony G: 10 articles (01/2022 - 01/2009)
3.	Brodie, Martin J: 9 articles (01/2020 - 12/2004)
4.	Keck, Paul E: 8 articles (11/2013 - 01/2004)
5.	McElroy, Susan L: 7 articles (11/2013 - 01/2004)
6.	Miwa, Hideto: 7 articles (09/2011 - 08/2003)
7.	Hasegawa, Kazuko: 6 articles (01/2022 - 01/2007)
8.	Supuran, Claudiu T: 6 articles (04/2020 - 01/2007)
9.	Abou-Khalil, Bassel: 6 articles (10/2018 - 05/2004)
10.	Bourgeois, Blaise: 6 articles (10/2018 - 05/2004)

Related Diseases

1.	Seizures (Absence Seizure) 12/01/2004 - "We conclude that zonisamide is highly effective for partial seizures and generalized seizures, and that there appears to be no decrease in efficacy with long-term use." 12/01/2004 - "Zonisamide was highly effective for treating partial seizures, with 70% of patients reporting improvement. " 01/01/1998 - "Zonisamide dramatically reduced the amount of myoclonias and generalized seizures. " 01/01/2014 - "At 5 years of age, addition of zonisamide further reduced the frequency of seizure episodes, but failed to achieve complete control of seizures. " 12/01/2004 - "Median percent reduction in partial seizures from baseline was significantly greater in zonisamide-treated patients compared to those receiving placebo (31.6% versus 3.3%, respectively; P = 0.008). "
2.	Epilepsy (Aura) 03/01/2005 - "Zonisamide is clinically effective against multiple seizure types in a significant proportion of children with epilepsy across a broad age range. " 01/01/2023 - "To assess the therapeutic efficacy and safety of antiseizure medication (ASM) for a minimum of 6 months, including zonisamide (ZNS), in feline idiopathic epilepsy at a referral hospital in Japan. " 11/01/2012 - "Based on these results, zonisamide monotherapy is effective in some dogs with idiopathic epilepsy." 04/01/1998 - "Zonisamide (ZNS) is effective in animal models of epilepsy and epileptic patients. " 12/01/2015 - "Safety and Efficacy of Zonisamide in Patients with Epilepsy: A Post-Marketing Surveillance Study."
3.	Partial Epilepsies (Epilepsy, Partial) 08/01/2013 - "Adjunctive zonisamide treatment was shown to be effective and well tolerated in pediatric patients with partial epilepsy. " 02/01/2013 - "Zonisamide seems to be effective and safe in focal epilepsy. " 06/01/2019 - "An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy." 04/01/2014 - "To investigate the safety/tolerability and efficacy of long-term adjunctive zonisamide and its impact on growth and development in children (6-18 years) with partial epilepsy. " 01/01/2005 - "To evaluate the safety and efficacy of zonisamide (ZNS) as adjunctive treatment in patients with refractory localization-related epilepsy. "
4.	Parkinson Disease (Parkinson's Disease) 04/01/2010 - "The addition of zonisamide at 25-50 mg/day to currently used antiparkinsonian drugs significantly improved cardinal symptoms in patients with advanced Parkinson's disease. " 01/01/2021 - "Zonisamide for the Efficacy of Sleep Abnormality in Parkinson's Disease (ZEAL Study): A Protocol for Randomized Controlled Trials." 09/01/2009 - "A multicentered, randomized, double-blind, placebo-controlled study conducted in Japan suggested that zonisamide, as an add-on treatment, has efficacy in treating motor symptoms in patients with Parkinson's disease. " 09/01/2007 - "A multicentered, randomized, double-blind, placebo-controlled study conducted in Japan provided data suggesting that zonisamide, as an add-on treatment, has efficacy in treating motor symptoms in patients with Parkinson's disease (PD). " 02/14/2022 - "Zonisamide Ameliorates Microglial Mitochondriopathy in Parkinson's Disease Models."
5.	Infantile Spasms (West Syndrome) 12/01/2009 - "Although further study of zonisamide is warranted, high-dose zonisamide can be effective and safe in some infants with newly diagnosed West syndrome." 03/01/2020 - "A series of relatively small studies collectively suggest that zonisamide may be effective in the treatment of infantile spasms. " 09/01/2000 - "We determined that zonisamide was effective in three epileptic infants with hypsarrhythmia. " 03/01/2020 - "Limited efficacy of zonisamide in the treatment of refractory infantile spasms." 05/01/1999 - "[Efficacy of zonisamide in West syndrome]."

Related Drugs and Biologics

1.	Topiramate (Topamax)
2.	Levetiracetam (Keppra)
3.	Lamotrigine (Lamictal)
4.	Valproic Acid (Depakote)
5.	Carbamazepine (Tegretol)
6.	Anticonvulsants (Antiepileptic Drugs)
7.	Oxcarbazepine (Trileptal)
8.	Gabapentin (Neurontin)
9.	Phenobarbital (Luminal)
10.	Lacosamide

Related Therapies and Procedures

1.	Therapeutics
2.	Vagus Nerve Stimulation
3.	Relaxation Therapy (Relaxation Technique)
4.	Psychology Biofeedback (Biofeedback)
5.	Drug Therapy (Chemotherapy)