Piperazine

An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.

Also Known As:

1,4-Diazacyclohexane; 1,4-Piperazine; Piperazine Diacetate; Piperazine Dihydrochloride; Piperazine Hexahydrate; Piperazine Hydrate; Piperazine Hydrobromide; Piperazine Hydrochloride; Piperazine Monohydrochloride; Piperazine Phosphate; Piperazine Phosphate (1:1); Piperazine Phosphate Anhydrous; Piperazine Salt; Piperazine Sulfate; Piperazine Tartrate; Piperazine Tartrate (1:1), (R-(R*,R*))-isomer; Piperazine Tartrate, (R-(R*,R*))-isomer; Piperazinium Oleate; Pripsen; 1,4 Diazacyclohexane; 1,4 Piperazine

Networked: 660 relevant articles (33 outcomes, 71 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - Piperazine: 660
      - enzaplatovir: 1
      - JHU37160: 1

Experts

1.	Li, Bo: 4 articles (04/2022 - 07/2018)
2.	Menegatti, Ricardo: 4 articles (01/2021 - 12/2015)
3.	Supuran, Claudiu T: 4 articles (03/2020 - 08/2009)
4.	Guo, Qinglong: 4 articles (01/2018 - 01/2009)
5.	Li, Zhiyu: 4 articles (01/2018 - 01/2009)
6.	Lu, Na: 4 articles (01/2018 - 06/2011)
7.	Abate, Carmen: 4 articles (01/2017 - 12/2009)
8.	Berardi, Francesco: 4 articles (01/2017 - 12/2009)
9.	Liu, Rong: 3 articles (04/2022 - 11/2020)
10.	Zeng, Nan: 3 articles (04/2022 - 11/2020)

Related Diseases

1.	Infections 07/30/1988 - "A controlled trial was performed to evaluate the efficacy of piperazine dihydrochloride in a new granular formulation (Ascarex D) against naturally occurring infections with Ascaris suum, Oesophagostomum dentatum and O quadrispinulatum. " 01/01/1988 - "The efficacy of piperazine dihydrochloride (Ascarex D, Rexolin Chemicals AB, Helsingborg, Sweden) was evaluated against natural infections of Ascaridia galli in broiler breeders. " 10/01/1966 - "[Trial of a mixture of piperazine and pryvinium in the treatment of ascaris and oxyuris infections]." 04/01/2022 - "duodenale) infection was measured after starting treatments with piperazine. " 05/01/1995 - "Piperazine has been used to treat pinworm and roundworm infections for over 40 years. "
2.	Neoplasms (Cancer) 06/01/2021 - "IMID-2, a newly identified piperazine-based anticancer molecule, has been shown to be cytotoxic against various cancer cell lines. " 03/01/2019 - "Some compounds containing a piperazine moiety displayed moderate to high levels of antitumor activities against the tested cancer cell lines. " 01/01/2019 - "Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor, fails to kill human cancer cells in vitro. " 05/10/2018 - "One of the compounds, 8, containing a terminal piperazine appendage with a carboxamide moiety at position 8 and phenyl group at position 9 of 6-chloro-8,9-dihydro-7H-purine core, showed the most potent antiproliferative activity and good selectivity between cancer and normal cells (IC50 values of 2.80 μM against A549 and 303.03 μM against GES-1, respectively). " 01/01/2016 - "The presence of naphthyl, benzhydryl, benzoyl, furoyl and heterocyclic rings on the piperazine system was essential to exert anticipated cytotoxic effects against cancer cell lines. "
3.	Alzheimer Disease (Alzheimer's Disease) 10/01/2023 - "Design and development of benzyl piperazine linked 5-phenyl-1,2,4-triazole-3-thione conjugates as potential agents to combat Alzheimer's disease." 02/01/2009 - "Synthesis and enzymatic evaluation of new series of N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors for the treatment of Alzheimer's disease are reported." 03/01/2015 - "Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease." 01/01/2023 - "Late-stage functionalizations of enantioenriched piperazine derivatives were demonstrated, including synthesis of a drug compound with glycogen synthase kinase (GSK)-3β inhibitor activity with potential for treating Alzheimer's disease." 10/01/2019 - "In the designed research work, a series of 2-furoyl piperazine based sulfonamide derivatives were synthesized as therapeutic agents to target the Alzheimer's disease. "
4.	Diabetic Nephropathies (Diabetic Nephropathy) 02/01/2022 - "PubMed, Embase, Cochrane Library, Wangfang, VIP, and CNKI database (until March 17, 2021) were comprehensively searched for randomized controlled trials investigating the effects of adding piperazine ferulate to ARBs in diabetic nephropathy patients. " 02/01/2022 - "Adding piperazine ferulate to ARBs may achieve additional renal protective benefits, particular in early diabetic nephropathy patients." 11/01/2020 - "Therapeutic Efficacy of Piperazine Ferulate Combined With Irbesartan in Diabetic Nephropathy: A Systematic Review and Meta-analysis." 03/01/2019 - "Piperazine ferulate ameliorates the development of diabetic nephropathy by regulating endothelial nitric oxide synthase." 02/01/2022 - "Improving renoprotective effects by adding piperazine ferulate and angiotensin receptor blocker in diabetic nephropathy: a meta-analysis of randomized controlled trials."
5.	Tuberculosis (Tuberculoses) 11/01/2001 - "The N1-p-hydroxylphenyl substituted compound 22 and the methoxyphenyl substituted compound missing the piperazine ring 12 were identified as promising candidates for the further development of an improved treatment of tuberculosis. " 01/01/2007 - "Hydrophilic cyclic secondary amines were substituted to the core scaffold and a benzyl piperazine substitution was found to be most effective in achieving improved solubility and potent anti-tuberculosis activity. " 11/01/2020 - "A piperazine-containing benzothiazinones lead compound PBTZ169, served as DprE1 inhibitor, displays nanomolar bactericidal activity against Mycobacteria tuberculosis. " 08/15/2017 - "Development and validation of a highly sensitive LC-ESI-MS/MS method for estimation of IIIM-MCD-211, a novel nitrofuranyl methyl piperazine derivative with potential activity against tuberculosis: Application to drug development." 11/01/2009 - "Both isoprenyl PCU tetra-amine derivatives and N-decyl piperazine PCU (9a) were highly active against the XDR 194 strain of tuberculosis with MICs in the range of 0.63-3.02 microM. "

Related Drugs and Biologics

1.	N-(4-acetyl-1-piperazinyl) -4-fluorobenzamide monohydrate
2.	Piperazine
3.	Pyrantel
4.	Levamisole (Decaris)
5.	Tablets
6.	Mebendazole (Anti-Worm)
7.	Salts
8.	Anthelmintics
9.	benzothiazole
10.	AJ 3941

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
4.	Analgesia
5.	Drug Therapy (Chemotherapy)