New N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors.

Abstract	Synthesis and enzymatic evaluation of new series of N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors for the treatment of Alzheimer's disease are reported.
Authors	Y Laras, C Garino, J Dessolin, C Weck, V Moret, A Rolland, J-L Kraus
Journal	Journal of enzyme inhibition and medicinal chemistry (J Enzyme Inhib Med Chem) Vol. 24 Issue 1 Pg. 181-7 (Feb 2009) ISSN: 1475-6374 [Electronic] England
PMID	18770069 (Publication Type: Journal Article)
Chemical References	Amides Amyloid beta-Peptides Carboxylic Acids Piperazines Protease Inhibitors Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases BACE1 protein, human naphthenic acid
Topics	Alzheimer Disease (drug therapy) Amides Amyloid Precursor Protein Secretases (antagonists & inhibitors) Amyloid beta-Peptides Aspartic Acid Endopeptidases (antagonists & inhibitors) Carboxylic Acids (chemistry, pharmacology) Humans Piperazines (chemistry, pharmacology) Protease Inhibitors (therapeutic use)

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