Lamotrigine (Lamictal)

A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.

Also Known As:

Lamictal; 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine; BW-430C; Crisomet; Labileno; Lamiktal; BW 430C; BW430C; 1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-

Networked: 2938 relevant articles (476 outcomes, 632 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Triazines: 306
    - Lamotrigine: 2938

Experts

1.	Calabrese, Joseph R: 28 articles (12/2014 - 01/2002)
2.	Hammer, Anne E: 24 articles (08/2014 - 02/2003)
3.	Marson, Anthony G: 23 articles (01/2022 - 03/2005)
4.	Ketter, Terence A: 23 articles (01/2020 - 02/2002)
5.	Bowden, Charles L: 23 articles (08/2013 - 10/2002)
6.	Vuong, Alain: 19 articles (08/2014 - 02/2001)
7.	Vieta, Eduard: 16 articles (11/2022 - 08/2003)
8.	Messenheimer, John A: 14 articles (08/2014 - 08/2004)
9.	Tomson, Torbjörn: 13 articles (01/2022 - 09/2004)
10.	Pennell, Page B: 13 articles (01/2019 - 07/2004)

Related Diseases

1.	Seizures (Absence Seizure) 08/01/1990 - "Although there was no significant reduction in total seizure count during the lamotrigine treatment period compared to placebo, there appears to be a drug effect as there was a marked reduction in generalized tonic-clonic seizures in favour of lamotrigine in the last 4 weeks of the treatment period. " 02/01/2007 - "Median percentage reductions in seizure frequency were significantly greater with lamotrigine than placebo during the escalation phase, the maintenance phase, and the escalation and maintenance phases combined for PGTC seizures and all generalized seizures. " 11/10/1999 - "Compared with placebo, lamotrigine significantly reduced the frequency of all partial seizures and the frequency of secondarily generalized partial seizures in these treatment-resistant patients. " 10/01/1996 - "There was a statistically significant reduction in seizure counts on lamotrigine compared with placebo for total seizures (30.3% reduction, 95% CI 8.4%, 47.0%), complex partial seizures (29.2% reduction, 95% CI 3.8%, 47.9%) and secondary generalised seizures (37.9%, CI 18.9%, 52.4%). " 11/01/1989 - "There was a modest statistically significant reduction in total and partial seizures on lamotrigine compared to placebo treatment. "
2.	Bipolar Disorder (Manic Depressive Psychosis) 10/01/2002 - "Lamotrigine has undergone a remarkable series of systematic studies since 1994 that now establish it as an efficacious, well-tolerated treatment in bipolar disorder. " 05/01/2000 - "Lamotrigine has the most evidence in favor of its efficacy, with two double-blind studies in which it was more efficacious than placebo in the treatment of bipolar depression. " 05/19/2014 - "In contrast, lamotrigine, a mood stabilizer, has been proven to be effective in preventing depression in patients with bipolar disorder. " 04/01/2003 - "Lamotrigine has been shown to be an effective treatment for bipolar depression and rapid cycling in placebo-controlled clinical trials. " 11/01/2000 - "This was the largest and only prospective placebo-controlled study of rapid-cycling bipolar disorder patients to date; results indicate lamotrigine monotherapy is a useful treatment for some patients with rapid-cycling bipolar disorder."
3.	Epilepsy (Aura) 12/16/2001 - "The new anti-epileptic drugs have a major therapeutic advantage, not only in the management of epilepsy in different clinical situations, but also in the good results observed when using lamotrigine in patients of fertile age." 03/01/1998 - "Lamotrigine (LTG) is a valuable addition to the medical management of epilepsy with wide spectrum of efficacy and good outcomes for quality of life. " 01/01/2020 - "Evidence suggests that lamotrigine could be effective in reducing aura frequency and duration. " 01/01/2008 - "The AED lamotrigine has been demonstrated to be effective in the treatment of depressive symptoms in patients with epilepsy. " 10/01/2007 - "Review of the available literature suggests lamotrigine is effective and well tolerated in elderly patients with epilepsy and relatively well-tolerated and may be effective in delaying mood relapse, particularly in the depressive pole, in patients with BD. "
4.	Mania (Manias) 05/01/2006 - "The base-case model for patients with a recent manic episode indicated that lamotrigine is the most effective treatment for avoiding both acute depression episodes and all types of acute episodes (depression and mania). " 07/01/2006 - "OFC-treated patients had significantly greater improvement than lamotrigine-treated patients in change from baseline across the 7-week treatment period on the Clinical Global Impressions-Severity of Illness scale (primary outcome) (p = .002, effect size = 0.26), Montgomery-Asberg Depression Rating Scale (MADRS) (p = .002, effect size = 0.24), and Young Mania Rating Scale total scores (p = .001, effect size = 0.24). " 06/01/2018 - "Therefore our results indicate that there is an association between baseline-assessed lifetime hypomania scores and higher remission and lower relapse rates during 6-month lamotrigine treatment indicating the efficacy of lamotrigine among patients with hypomania during their illness course." 03/01/2004 - "Lamotrigine was effective against depression and mania, with more robust activity against depression. " 01/01/2010 - "Lamotrigine may be preferably effective in the treatment of depression but not mania. "
5.	Pain (Aches) 08/01/1998 - "Recent evidence suggests that lamotrigine, which is active at glutaminergic excitatory synapses, is very effective in producing pain relief. " 01/23/2001 - "Oral lamotrigine 200 mg daily is a well tolerated and moderately effective treatment for central poststroke pain. " 06/13/2000 - "In this small trial, lamotrigine showed promise in the treatment of pain associated with HIV-related DSP. " 11/01/2002 - "With 75-300 mg of lamotrigine per day, the burning and shooting pain intensity was relieved by 33-100%. " 06/01/2000 - "One small clinical trial with lamotrigine demonstrated improved pain control in TN. "

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	Valproic Acid (Depakote)
3.	Carbamazepine (Tegretol)
4.	Topiramate (Topamax)
5.	Gabapentin (Neurontin)
6.	Levetiracetam (Keppra)
7.	Lithium
8.	Felbamate (Felbatol)
9.	Vigabatrin
10.	Zonisamide (Zonegran)

Related Therapies and Procedures

1.	Therapeutics
2.	Vagus Nerve Stimulation
3.	Drug Therapy (Chemotherapy)
4.	Ketogenic Diet
5.	Aftercare (After-Treatment)