Solitary Kidney

Either a single or a single functioning kidney due to NEPHRECTOMY, birth defects or other kidney diseases.

Also Known As:

Single Functioning Kidney; Single Kidney; Solitary Functioning Kidney; Unilateral Renal Agenesis; Unilateral Renal Hypoplasia; Functioning Kidney, Single; Functioning Kidneys, Single; Kidney, Single; Kidney, Single Functioning; Kidneys, Single; Kidneys, Single Functioning; Renal Agenesis, Unilateral; Renal Hypoplasia, Unilateral; Single Functioning Kidneys; Single Kidneys

Networked: 1542 relevant articles (64 outcomes, 111 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Shock
3.	Carcinoma (Carcinomatosis)
4.	Hypertension (High Blood Pressure)
5.	Chronic Renal Insufficiency

Experts

1.	Lerman, Lilach O: 23 articles (12/2020 - 08/2002)
2.	Kaouk, Jihad H: 18 articles (05/2022 - 02/2005)
3.	Lerman, Amir: 15 articles (12/2020 - 08/2002)
4.	Gill, Inderbir S: 15 articles (02/2013 - 09/2002)
5.	Textor, Stephen C: 12 articles (01/2020 - 12/2006)
6.	Novick, Andrew C: 10 articles (11/2009 - 01/2002)
7.	Campbell, Steven C: 9 articles (05/2021 - 09/2010)
8.	Krier, James D: 9 articles (12/2020 - 08/2002)
9.	Cadeddu, Jeffrey A: 9 articles (01/2020 - 04/2008)
10.	Lane, Brian R: 9 articles (08/2013 - 03/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Solitary Kidney:

1.	CreatinineIBA 12/01/2020 - "A significant improvement was detected in creatinine and glomerular filtration rate levels in the sixth months after surgery in solitary kidney patients (p < .05). " 02/01/1994 - "In 17 patients with a preoperative serum creatinine clearance of 1.5 mg/dl or less who underwent SWL to a solitary kidney, the glomerular filtration rate (GFR) was calculated by the formula of Cockcroft and Gault, which correlates significantly with measured creatinine clearance. " 07/01/1999 - "Donors for dual kidney recipients had a lower donor admission creatinine clearance of 82 +/- 28 mL/min versus 105 +/- 45 mL/min in the single kidney group (p = 0.005). " 01/01/2020 - "The objective of our study was to develop a novel method to estimate single-kidney glomerular filtration rate (GFR) using a combination of contrast-enhanced CT and serum creatinine (SCr) values and to validate the resulting estimated glomerular filtration rates (eGFRs) by comparing them with the single-kidney Gates GFR, which is based on renal dynamic imaging. " 01/01/2018 - "Based on the parameter characteristics, the study population was divided into following four groups: (a) patients with reduced GFR and maintained ERPF and normal serum creatinine (n = 3); (b) patients with reduced ERPF with maintained GFR and borderline elevated/normal serum creatinine (n = 3); (c) patients with both reduced GFR and ERPF and maintained serum creatinine (n = 1); (d) patients with compromised single kidney function (n = 5). "
2.	Inulin FDA Link 11/01/2003 - "This study defined the growth parameters for single kidneys during childhood and correlated them with inulin clearance. " 05/01/2013 - "The eGFR-CKiD2 equation performed best in children with a solitary functioning kidney (mean bias, -0.9 ml/min per 1.73 m(2); 95% and 54% of values within ±30% and ±10% of GFR-inulin, respectively). " 11/01/2003 - "Data were obtained from 74 children (40 boys and 34 girls) drawn from a registry of cases with a single kidney, and in whom simultaneous measurements of inulin clearance and renal length had been made at around 5, 10, and 16 years of age. " 11/01/2003 - "Renal length and inulin clearance in the radiologically normal single kidney." 04/01/2002 - "Direct measurements of renal venous and arterial inulin concentration provided reference standard estimates of single-kidney EF. "
3.	Cisplatin (Platino)FDA LinkGeneric 07/01/1996 - "We describe a 78-year-old woman with a single kidney who developed nephrotoxicity following a single evening dose of cisplatin. " 07/01/1996 - "Although many clinicians believe that cisplatin nephrotoxicity is unlikely to occur in patients with a single kidney, recent reports have suggested otherwise. " 07/01/1996 - "To describe a patient with a single kidney who experienced cisplatin-associated nephrotoxicity. " 07/01/1996 - "Cisplatin nephrotoxicity in a patient with a single kidney." 01/01/2018 - "The results suggest that cisplatin-based chemotherapy may have more nephrotoxicity in patients with bilateral-functioning kidneys than in those with a solitary-functioning kidney."
4.	SodiumIBA 01/01/2011 - "These changes were paralleled by decreased urinary sodium excretion and a significant reduction in urinary osmolality from the obstructed kidney, suggesting a functional association between the molecular changes and the ability of the obstructed kidney to handle sodium and water in this solitary kidney model." 04/01/1975 - "Various fasting periods were employed, but with none of them did rats with a single kidney exhibit sodium retention. " 01/01/2023 - "A solitary functioning kidney (SFK) from birth predisposes to hypertension and kidney dysfunction, and this may be associated with impaired fluid and sodium homeostasis. " 04/15/2014 - "A congenital SFK is present in patients with unilateral renal agenesis or unilateral multicystic kidney dysplasia, leading to both structural and functional adaptations in the remaining kidney, which act to mitigate the reductions in glomerular filtration rate and sodium excretion that would otherwise ensue. " 11/01/2002 - "Patients with atheromatous stenosis in a single functioning kidney, and those who present with signs of sodium and water retention, are likely to benefit most."
5.	Oxygen (Dioxygen)IBA 10/06/2016 - "We compared the maximal oxygen uptake (VO2 max) of children with a functioning renal transplant with that of children with congenital solitary functioning kidney, taking into consideration also the amount of weekly sport activity." 06/01/1995 - "No significant improvement was seen in single-kidney renal blood flow (184 +/- 108 vs 193 +/- 107 mL/min), renal oxygen delivery (28 +/- 16 vs 30 +/- 16 mL/min), or renal oxygen consumption (4.9 +/- 2.0 vs 4.7 +/- 2.5 mL/min) in response to 1:1 counterpulsation. " 08/01/1991 - "Data from patients after simultaneous pancreas and kidney transplantation revealed an improvement in transcutaneous oxygen pressure measurement, reoxygenation time and laser speckle measurement whereas the control group with solitary kidney transplantation did not show a positive evaluation. "
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 08/01/1996 - "Renal allograft function and results with cyclosporine immunosuppression in recipients of single kidneys from cadaveric donors aged 12 to 24 months." 03/01/2004 - "Many studies, although not all, have documented a positive RFR in both children and adult cyclosporine-treated kidney graft recipients, demonstrating that hyperfiltration is not the rule following single kidney transplantation." 01/01/2000 - "These drugs have not gained wide acceptance in the treatment of hypertension in renal transplant recipients (RTRs) because of a potential for decreased renal blood flow and glomerular filtration rate associated with a single kidney and concomitant cyclosporine use. " 04/01/1993 - "We tested this hypothesis in a canine single kidney model of cyclosporin-enhanced ischemic renal failure. " 07/01/2004 - "We prospectively evaluated 94 first solitary kidney transplant patients treated with cyclosporine (Neoral), MMF, and prednisone. "
7.	Captopril (Capoten)FDA LinkGeneric 03/01/1999 - "Predictive value of 99Tcm-DTPA captopril scintigraphy in patients with a solitary kidney and reduced kidney function." 11/01/1993 - "Captopril renal scintigraphy may therefore be suggested as a reliable and safe noninvasive approach to evaluate hypertensive patients with a solitary kidney." 11/01/1993 - "Evaluation of hypertensive patients with a solitary kidney using captopril renal scintigraphy with 99Tcm-MAG3." 06/03/1991 - "The captopril renography was performed with 99mTc-DTPA by means of a gammacamera, allowing determination of single kidney glomerular filtration rate (SKGFR). " 01/01/1988 - "Effect of captopril on renal function during exercise in a patient with unilateral renal agenesis."
8.	AcidsIBA 01/01/2001 - "At ages 4, 12 and 24 weeks single kidney function was assessed using 99mtechnetium diethylenetriaminepentaacetic acid differential uptake on renography combined with the glomerular filtration rate estimated from the plasma clearance of 99mtechnetium diethylenetriaminepentaacetic acid. " 05/27/1994 - "As judged by the glomerular filtration rate, which was elevated for a single kidney (76 +/- 4 ml/min 1.73 m2), allograft function was excellent, permitting the assumption of unimpaired renal extraction of paminohippuric acid (PAH). " 03/01/1971 - "Urinary concentration, dilution and acid excretion in subjects with a single kidney." 01/01/1989 - "Total GFR was measured by the plasma disappearance of Tc-99m-diethylenetriaminepentaacetic acid (DTPA) after bolus injection and single-kidney GFR from renal uptake of DTPA assessed by renography. " 10/01/1988 - "The extraction factor: an estimate of single kidney function in children during routine radionuclide renography with 99mtechnetium diethylenetriaminepentaacetic acid."
9.	Tacrolimus (Prograf)FDA LinkGeneric 08/15/2014 - "Retrospective chart review was performed of all single-kidney-only transplants in our Renal Transplant Program from March 2004 to March 2010 (n=117) whose immunosuppressive regimen included tacrolimus (n=81). " 08/01/2014 - "To evaluate bladder histology in healing and biochemical analysis of rats with single kidney in ischemia/reperfusion, treated with tacrolimus. " 08/01/2014 - "Analysis of the histology of the scar bladder and biochemical parameters of rats with a solitary kidney undergoing immunosuppression with tacrolimus." 01/01/2019 - "The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center." 02/01/2009 - "We extend our report of the first 200 consecutive living donor solitary kidney transplantations under alemtuzumab pretreatment with tacrolimus monotherapy and subsequent spaced weaning to 3 years of follow-up. "
10.	Cystatin CIBA 10/01/2012 - "The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). " 05/01/2006 - "The aim of the study was to assess serum cystatin C level in children with a congenital solitary kidney, depending on their age and compensatory overgrowth of the kidney. " 01/01/2015 - "To determine the direct relationship between echogenicity and GFR, we retrospectively analyzed 91 patients with a solitary functioning kidney under the age of 10, who underwent ultrasonography and serum cystatin C evaluation on a single day between January 2013 and December 2014. " 05/01/2006 - "We conclude that Increased serum cystatin C concentration in patients with a unilateral congenital solitary kidney occurs after 12 years of age and correlates with compensatory overgrowth of the kidney." 05/01/2006 - "Assessment of serum cystatin C in children with congenital solitary kidney."

Therapies and Procedures

1.	Nephrectomy 05/01/2013 - "Robot-assisted partial nephrectomy represents a safe and effective minimally-invasive treatment option for renal masses in patients with a solitary kidney. " 11/01/2005 - "Nephron-sparing surgery (NSS), originally developed to treat RCC arising in a solitary functioning kidney, has been demonstrated to be a safe and effective alternative to radical nephrectomy. " 08/01/2012 - "At present, open partial nephrectomy is the gold standard treatment for an SRM in a solitary kidney; however, there are a number of other minimally invasive options, including laparoscopic partial nephrectomy, and in situ ablative procedures. " 01/01/2019 - "To study the short and intermediate surgical, renal functional, and oncologic outcomes of multiplex partial nephrectomy (mPN) and standard partial nephrectomy (sPN) in the setting of a solitary kidney. " 01/01/2017 - "To study pregnancy outcome in patients with solitary kidney either congenital or due to nephrectomy. "
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 03/01/2023 - "Predictors of stone-free rate after a single-session extracorporeal shockwave lithotripsy for a single kidney stone measuring 10 to 20 mm: A private center experience." 12/01/2021 - "To compare perioperative outcomes and long-term renal function changes between prior stenting (PS) and not prior stenting (NPS) before flexible ureteroscopy lithotripsy (f-URS) for solitary kidney patients. " 12/01/2021 - "The feasibility of one-stage flexible ureteroscopy lithotripsy in solitary kidney patients with 1-3 cm renal stones and risk factors of renal function changes." 05/01/1997 - "[Extracorporeal lithotripsy of stones in the single kidney]." 03/01/1995 - "[Extracorporeal shockwave lithotripsy in single kidneys. "
3.	Transplantation 04/27/1999 - "Calculated donor CrCl and donor vascular pathology predict recipient graft function and may be helpful in selecting high-risk donors for single kidney transplantation." 09/01/2022 - "HMP yielded promising results in kidneys with Karpinski Score >3. Initial RR should be of interest in selecting non-standard organs for single kidney transplantation even in impaired histology." 06/01/2023 - "The present study consecutively collected 306 patients who underwent their first single kidney transplantation (KT) from adult deceased donors in our center from January 1, 2018 to December 31, 2019. " 04/01/2021 - "A Descriptive Study of Late Intensive Care Unit Admissions After Adult Solitary Kidney Transplantation." 01/01/2020 - "Our study suggests that single kidney transplantation from donors weighing over 5 kg to pediatric recipients is a feasible option for children with poor access to transplantation."
4.	Percutaneous Nephrolithotomy 08/01/2022 - "Is percutaneous nephrolithotomy effective and safe for children with solitary kidney?" 03/01/2012 - "To demonstrate the safety and efficacy of percutaneous nephrolithotomy (PCNL) for management of large renal stones between single-functioning kidney and double-kidney patients. " 11/01/2023 - "The goal of this study is to compare traditional percutaneous nephrolithotomy (PCNL) and needle-perc-assisted endoscopic surgery (NAES) in the treatment of complicated solitary kidney stones via a single-center randomized controlled prospective study. " 01/01/2022 - "The aim of the study was to compare the treatment outcomes between suctioning flexible ureteroscopic lithotomy (SF-URL) with automatic control of renal pelvic pressure and minimally invasive percutaneous nephrolithotomy (MPCNL) for the management of 2-3-cm renal stones in patients with a solitary kidney. " 04/01/2016 - "The objective of the study was to analyze the treatment outcomes for staghorn stones in patients with solitary kidney using either the single-tract or the multi-tract minimally invasive percutaneous nephrolithotomy (MPCNL). "
5.	Radiofrequency Ablation 06/01/2012 - "Radiofrequency ablation in the solitary kidney is a safe and effective procedure for treating RCC." 07/01/2013 - "To evaluate the long-term results of percutaneous radiofrequency ablation (RFA) of small renal tumours in patients with a single functioning kidney (SFK). " 07/01/2013 - "Percutaneous radiofrequency ablation of small renal tumours in patients with a single functioning kidney: long-term results." 04/01/2013 - "Although the mean glomerular filtration rate at 1 year after radiofrequency ablation was similar to the baseline value in 26 patients with bilateral kidneys (P = .14), it was decreased significantly in six patients with a single kidney (P = .03). " 03/01/2010 - "Radiofrequency ablation of kidney tumours in patients with a solitary kidney."