Pharmacological manipulation of acute cyclosporin ischemic renal injury with trimetazidine.

Abstract

Cyclosporin has had a major impact on organ transplantation, but associated nephrotoxicity is a significant problem. Renal hypothermia, a known anti-ischemic maneuver, limits cyclosporin-ischemic renal failure. Pharmacological manipulation with an anti-ischemic agent, such as trimetazidine, may prevent cyclosporin nephrotoxicity. We tested this hypothesis in a canine single kidney model of cyclosporin-enhanced ischemic renal failure. Trimetazidine treatment was associated with significantly better biochemical and histological markers of renal function and structure. Trimetazidine may have a role to play in protecting against cyclosporin nephrotoxicity in clinical renal transplantation.

• Authors: T Creagh, D Lanigan, J Dolan, W Tormey, J J Walshe, D Bouchier-Hayes
• Journal: The Journal of urology (J Urol) Vol. 149 Issue 4 Pg. 915-7 (Apr 1993) ISSN: 0022-5347 [Print] United States
• PMID: 8455274 (Publication Type: Journal Article)

Chemical References

• Cyclosporine
• Trimetazidine

Topics

• Animals
• Cyclosporine (adverse effects)
• Dogs
• Ischemia (chemically induced, prevention & control)
• Kidney (blood supply)
• Renal Insufficiency (chemically induced, prevention & control)
• Trimetazidine (therapeutic use)