Abstract | BACKGROUND: Few studies explored the role of hypothermic machine perfusion (HMP) in the sub-group of non-standard renal grafts with a biopsy-proven advanced histological impairment. This study aimed to investigate the role of HMP in grafts with a Karpinski Score >3 in terms of the need for dialysis, creatinine reduction ratio at day-7 (CRR7), and 3-year graft survival. METHODS: Twenty-three perfused grafts with Karpinski Score >3 evaluated between November 2017 and December 2018 were retrospectively analyzed and compared with a control group of 32 non-perfused grafts transplanted between January 2014 and October 2017. RESULTS: After transplantation, perfused grafts had fewer cases requiring dialysis (8.7% vs. 34.4%; p = 0.051), a better reduction in serum creatinine (median at 7 days: 2.2 vs. 4.3 mg/dl; p = 0.045), and shorter length of hospital stay (median 11 vs. 15 days; p = 0.01). Three-year death-censored graft survival was better in the perfused cases (91.3% vs. 77.0%; p = 0.16). In perfused grafts, initial renal resistance (RR) had the best predictive value for renal function recovery after the first week, as defined by CRR7 ≤ 70% (AUC = 0.83; p = 0.02). A cut-off value of 0.5 mm Hg/ml/min showed a sensitivity of 82.4%, a specificity of 83.3%, and diagnostic odds ratio = 23.4. After dividing the entire population into a Low-RR (n = 8) and a High-RR Group (n = 15), more cases with CRR7 ≤ 70% were reported in the latter group (86.7 vs. 13.3%; p = 0.03). CONCLUSION: HMP yielded promising results in kidneys with Karpinski Score >3. Initial RR should be of interest in selecting non-standard organs for single kidney transplantation even in impaired histology.
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Authors | Franco Ruberto, Quirino Lai, Mario Piazzolla, Matteo Brisciani, Renzo Pretagostini, Manuela Garofalo, Francesco Giovanardi, Francesco Nudo, Luca Poli, Veronica Zullino, Pietro Santopietro, Massimo Rossi, Pasquale B Berloco, Francesco Pugliese |
Journal | Artificial organs
(Artif Organs)
Vol. 46
Issue 9
Pg. 1771-1782
(Sep 2022)
ISSN: 1525-1594 [Electronic] United States |
PMID | 35548925
(Publication Type: Journal Article)
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Copyright | © 2022 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. |
Topics |
- Delayed Graft Function
(etiology)
- Graft Survival
- Humans
- Kidney
(surgery)
- Kidney Transplantation
(adverse effects, methods)
- Organ Preservation
(methods)
- Perfusion
(methods)
- Retrospective Studies
- Tissue Donors
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