NADPH Oxidase 4

An NADPH oxidase that is strongly expressed in the kidney. It forms a complex with CYBA-P22PHOX and produces intracellular SUPEROXIDES that may regulate cellular signaling in APOPTOSIS; BONE RESORPTION; and NF-KAPPA B activation.

Also Known As:

Networked: 272 relevant articles (11 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shah, Ajay M: 5 articles (01/2021 - 10/2017)
2.	Thannickal, Victor J: 5 articles (01/2020 - 04/2014)
3.	Brandes, Ralf P: 4 articles (01/2021 - 10/2017)
4.	Schröder, Katrin: 4 articles (01/2021 - 01/2016)
5.	Liu, Bing: 4 articles (01/2019 - 06/2014)
6.	Yang, Zhicheng: 4 articles (01/2019 - 06/2014)
7.	Wang, Feng: 3 articles (01/2022 - 01/2018)
8.	Carter, A Brent: 3 articles (01/2021 - 01/2017)
9.	Zhang, Min: 3 articles (01/2021 - 06/2014)
10.	Abboud, Hanna E: 3 articles (01/2020 - 05/2009)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2020 - "Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation." 09/01/2022 - "Suppression of NADPH oxidase 4 inhibits PM2.5-induced cardiac fibrosis through ROS-P38 MAPK pathway." 05/15/2022 - "In addition, LPS caused the upregulation of NADPH oxidase 4 and exacerbated lung fibrosis. " 12/01/2021 - "Interestingly, NADPH oxidase 4 (NOX4), implicated in lung fibrosis and cell senescence, was shown to be inhibited by RXM treatments. " 07/01/2021 - "NADPH oxidase 4 (NOX4) is the main source of ROS in hepatic fibrosis, but the mechanism by which NOX4 regulates oxidative stress is not fully understood. "
2.	Hypoxia (Hypoxemia) 05/07/2019 - "In our study, the reversal abilities of NADPH oxidase 4 (NOX4) silence on hypoxia resistance and the potential mechanism were investigated. " 03/01/2023 - "NADPH oxidase 4 was primarily expressed in hES-MSCs and generated ROS under hypoxia. " 03/01/2023 - "Hypoxia enhances the hair growth-promoting effects of embryonic stem cell-derived mesenchymal stem cells via NADPH oxidase 4." 10/01/2021 - "Thus, Nox4 protein levels were attenuated in hypoxia-treated cells resulting from p22phox depletion. " 01/01/2019 - "NADPH oxidase 4 is highly expressed in the DPC nuclear region, and NOX4 knockout by CRISPR-Cas9 attenuated the hypoxia-induced stimulation of DPCs. "
3.	Cardiomegaly (Heart Hypertrophy) 02/16/2017 - "NADPH oxidase 4 (NOX4) and the NOX4-related redox signaling are implicated in cardiac hypertrophy. " 01/01/2016 - "Consistently, treatment with the selective MR antagonist eplerenone blocked transverse aortic constriction-induced MR signaling and NADPH oxidase 4 gene upregulation, which improved cardiac hypertrophy and dysfunction. " 01/01/2023 - "Mechanistic studies indicate that FGF18/FGFR3 promote FYN activity and expression and negatively regulate NADPH oxidase 4 (NOX4), thereby inhibiting reactive oxygen species (ROS) generation and alleviating pathological cardiac hypertrophy. " 10/01/2023 - "Furthermore, to treat cardiac hypertrophy, CEVs are loaded with NADPH Oxidase 4 (NOX4) siRNA (siNOX4). " 01/01/2016 - "Pharmacological inhibition of Rac1 and heterozygous deletion of Rac1 in cardiomyocytes suppressed Rac1-induced MR signaling and reduced NADPH oxidase 4 gene induction and reactive oxygen species overproduction, which attenuated transverse aortic constriction-induced cardiac hypertrophy and dysfunction. "
4.	Hypertension (High Blood Pressure) 01/01/2023 - "We speculate that the significant diminution in AT 2, MAS, and NOX4 protein expressions may play an indirect role in the alteration and efficacy of gCAP and gLTP in hypertension." 09/01/2017 - "This study aimed to investigate the role of the NADPH oxidase 4 (Nox4)-induced ROS/RhoA/ROCK pathway in CIH-induced hypertension in rats. " 03/01/2015 - "The current study was designed to test the hypothesis that AT1R activation promotes renal NAD(P)H oxidase up-regulation, oxidative stress and cytokine production during L-NAME induced-hypertension. " 03/01/2015 - "Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension."
5.	Inflammation (Inflammations) 01/01/2021 - "In particular, the latter is supported by the NADPH oxidase 4 (Nox4) that constitutively produces low amounts of H2O2 By that mechanism, Nox4 forces differentiation of cells and prevents inflammation. " 10/01/2020 - "NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation." 01/01/2019 - "Furthermore, ablation of CD38 and NADPH oxidase 4 protected against UVB-induced inflammation and IL-1β secretion in the murine epidermis. " 11/01/2023 - "We tested the hypothesis that cardiomyocyte NOX4 (NADPH oxidase 4)-dependent mitochondrial oxidative stress mediates inflammation and diastolic dysfunction in stress cardiomyopathy. " 01/01/2017 - "We recently reported that increased NADPH oxidase 4 (NOX4) expression and activity during aging results in enhanced cellular and mitochondrial oxidative stress, vascular inflammation, dysfunction, and atherosclerosis. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Moxibustion
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4.	Hepatectomy