Intercellular Adhesion Molecule-3

A membrane glycoprotein and cell adhesion molecule expressed by LEUKOCYTES that contains multiple Ig-like domains. It is a ligand for LFA-1 (integrin alphaLbeta2) and integrin alpha-D/beta-2. Its interaction with LFA-1 may play a role in the PHAGOCYTOSIS of NEUTROPHILS by MACROPHAGES following APOPTOSIS.

Also Known As:

Networked: 122 relevant articles (0 outcomes, 16 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Geijtenbeek, Teunis B H: 4 articles (10/2021 - 03/2002)
2.	Du, Renle: 4 articles (01/2020 - 01/2018)
3.	Luo, Na: 4 articles (01/2020 - 01/2018)
4.	Shen, Wenzhi: 4 articles (01/2020 - 01/2018)
5.	Figdor, Carl G: 3 articles (10/2021 - 03/2002)
6.	Kaaks, Rudolf: 3 articles (01/2020 - 11/2017)
7.	Zhang, Xiaoyuan: 3 articles (01/2020 - 08/2018)
8.	Park, Jong Kuk: 3 articles (11/2013 - 11/2005)
9.	Yoo, Young Do: 3 articles (01/2010 - 11/2005)
10.	van Kooyk, Yvette: 3 articles (02/2007 - 03/2002)

Related Diseases

1.	Infections 03/13/2013 - "Dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin mediates HIV-1 infection of and transmission by M2a-polarized macrophages in vitro." 07/15/2007 - "No significant association to susceptibility to SARS infection caused by the novel coronavirus (SARS-CoV) was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. " 05/01/2005 - "Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells. " 06/01/2004 - "We demonstrate that intercellular adhesion molecule 3 (ICAM-3) acts as a costimulating molecule to increase HIV-1 transcription and viral production, a process allowing productive infection of quiescent CD4+ T lymphocytes. " 10/01/2009 - "Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection."
2.	Neoplasms (Cancer) 12/01/2022 - "Previous studies have identified several ICAM3 transcript variants and mainly investigated the function of the longest transcript of ICAM3 in various tumor progressions. " 01/01/2010 - "In this study, we hypothesized that ICAM-3 has an additional effect on cancer cell migration and invasion because molecules induced by ICAM-3 are known as regulators of cell migration and invasion. " 12/01/2022 - "Herein, we detected the expression of ICAM3 transcript variants 1-4 in DLBCL cells and tumor tissues, disclosed that variants 1, 3, and 4 were expressed in normal B cell lines and 3 DLBCL cell lines except SU-DHL-2 as well as tumor tissues, while variant 2 was not detected. " 01/01/2018 - "ICAM3 mediates inflammatory signaling to promote cancer cell stemness." 11/15/2013 - "The finding that ICAM-3 endows drug resistance as well as radioresistance supports its potential utility as a major therapeutic target against cancer. "
3.	Inflammation (Inflammations) 07/01/1995 - "In all types of lesions ICAM-3 was constitutively expressed on the majority of infiltrating leucocytes without detectable upregulation or presentation on possible target structures during inflammation indicating its possible role to be mainly in initiation of the inflammatory response." 01/01/2018 - "In summary, we identify a potential CSC regulator and suggest a novel mechanism by which ICAM3 governs cancer cell stemness and inflammation." 02/01/1996 - "Therefore, expression of ICAM-3 on blood vessels does not seem to play a role in the recruitment of leukocytes during inflammation but rather is correlated with angiogenesis and tumor development." 01/01/2021 - "The systemic and local expression of ITGAM, ITGB2, and ICAM-3 is significantly upregulated in CRSwNP, suggesting that integrin complex ITGAM/ITGB2 and ICAM-3 serve a potential role in inflammation-mediated signaling in CRSwNP." 01/01/2020 - "In addition, our results showed that aspirin inhibits inflammation-related stemness gene expression (especially ICAM3) identified by a high-throughput siRNA platform. "
4.	Stroke (Strokes) 01/01/2020 - "This study provides Class II evidence that plasma levels of ICAM3 are associated with increased stroke risk." 01/01/2020 - "In this population-based study, circulating levels of ICAM3, an adhesion molecule shed by leukocytes, were associated with increased risk of incident stroke. " 08/01/2021 - "Furthermore, regression analyses found that increased serum ICAM3 levels were associated with worse short-term functional outcomes of stroke. " 08/01/2021 - "Serum ICAM3 concentrations were higher in stroke patients than in healthy controls. " 01/01/2020 - "ICAM3 levels were associated with increased risk of incident stroke after multivariable adjustment (hazard ratio, highest vs lowest quartile: 1.64 [95% confidence interval, 1.15-2.32]; p linear trend < 0.001). "
5.	Skin Diseases (Skin Disease) 09/01/1995 - "In the present study, we investigated the expression of ICAM-3 in normal skin and in 98 biopsy specimens of various inflammatory and neoplastic dermatoses. " 09/01/1995 - "These results show that ICAM-3 is constitutively and widely expressed by cells participating in inflammatory dermatoses (including Langerhans cells and T and B lymphocytes), and that it can be, albeit rarely, induced on endothelial cells and dermal dendrocytes. " 09/01/1995 - "ICAM-3 was found to be expressed by epidermal CD1a+ Langerhans cells, by cells of Langerhans cell histiocytosis, by T and B lymphocytes infiltrating the dermis in cutaneous lymphomas and in a wide spectrum of inflammatory dermatoses. " 01/01/2003 - "Psoriasis is a chronic inflammatory T-cell-mediated immune dermatosis, characterized by the cutaneous expression of adhesion molecules belonging to the beta1 and beta2 integrin subfamilies, such as intracellular adhesion molecule (ICAM)-1, ICAM-3, lymphocyte function associated antigen (LFA)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial adhesion molecule (ELAM)-1. " 08/01/2009 - "To detect the profile of soluble CAMs in patients with cutaneous T-cell lymphoma (CTCL), we investigated the levels of intercellular adhesion molecule-1 (ICAM-1, soluble ICAM-1 [sICAM-1]); intercellular adhesion molecule-3 (sICAM-3); vascular cell adhesion molecule-1 (sVCAM-1); and E-selectin (sE-selectin) in sera from patients with T-cell-mediated skin diseases. "

Related Drugs and Biologics

1.	DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN)
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	Cell Adhesion Molecules
4.	P-Selectin
5.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
6.	E-Selectin
7.	Proteins (Proteins, Gene)
8.	Selectins
9.	Thrombomodulin
10.	Chemokine Receptors

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy