Intercellular adhesion molecule-3 on endothelial cells. Expression in tumors but not in inflammatory responses.

Abstract

Intercellular adhesion molecule-3 (ICAM-3) was identified as the third counter-receptor for lymphocyte function-associated antigen-1. ICAM-3 is absent on endothelial cells in normal tissues but found on endothelial cells in lymphomas. Here, we examined ICAM-3 expression on vascular endothelial cells in lymphomas, nonlymphoid malignancies, benign tumors, and inflammatory diseases. We compared the expression of ICAM-3 on endothelial cells with the severity of inflammatory infiltrates and with the presence of E-selectin and VCAM-1. We found that ICAM-3 expression on endothelial cells was high on both benign and malignant tumors whereas it was low in inflammatory diseases. In contrast to E-selectin, ICAM-3 expression on endothelial cells was not correlated to the severity of inflammatory infiltrates. In hemangiomas, we showed by Northern blot analysis and immunocytochemistry that ICAM-3 expression was induced and that it was localized in immature areas that sustain the early stages of angiogenesis. Therefore, expression of ICAM-3 on blood vessels does not seem to play a role in the recruitment of leukocytes during inflammation but rather is correlated with angiogenesis and tumor development.

• Authors: N Patey, R Vazeux, D Canioni, T Potter, W M Gallatin, N Brousse
• Journal: The American journal of pathology (Am J Pathol) Vol. 148 Issue 2 Pg. 465-72 (Feb 1996) ISSN: 0002-9440 [Print] United States
• PMID: 8579109 (Publication Type: Journal Article)

Chemical References

• Antigens, CD
• Antigens, Differentiation
• Biomarkers, Tumor
• Cell Adhesion Molecules
• E-Selectin
• ICAM3 protein, human
• Vascular Cell Adhesion Molecule-1

Topics

• Antigens, CD
• Antigens, Differentiation
• Biomarkers, Tumor
• Blotting, Northern
• Cell Adhesion Molecules (analysis, biosynthesis)
• E-Selectin (analysis, biosynthesis)
• Endothelium, Vascular (cytology, metabolism)
• Hemangioma (chemistry, metabolism)
• Hodgkin Disease (metabolism)
• Humans
• Immunoenzyme Techniques
• Inflammation (metabolism)
• Lymphoid Tissue (metabolism)
• Lymphoma (chemistry, metabolism)
• Lymphoma, Non-Hodgkin (metabolism)
• Neoplasms (metabolism)
• Neovascularization, Pathologic (physiopathology)
• Vascular Cell Adhesion Molecule-1 (analysis, biosynthesis)