Association of Circulating ICAM3 Concentrations with Severity and Short-term Outcomes of Acute Ischemic Stroke.

Abstract

Increased circulating intercellular adhesion molecule 3 (ICAM3) is associated with a risk of acute ischemic stroke. This study aims to investigate the association of serum levels of ICAM3 with the severity and short-term outcomes of ischemic stroke. This study recruited 152 stroke patients with supratentorial cerebral infarcts and 133 healthy controls. Patients were followed up for 2 weeks since admission for observation of functional outcomes. Serum ICAM3 concentrations at baseline were determined by Elisa. Serum ICAM3 concentrations were higher in stroke patients than in healthy controls. Serum concentrations of ICAM3 were not associated with stroke severity at baseline, as reflected by NIH Stroke Scale (NIHSS) and infarction volume. However, serum ICAM3 levels were positively associated with mRS scores at 2 weeks since admission. Furthermore, regression analyses found that increased serum ICAM3 levels were associated with worse short-term functional outcomes of stroke. These findings imply that circulating ICAM3 might be a potential short-term prognostic biomarker for acute ischemic stroke.

• Authors: Hu Zicheng, Yang Xiao, Huang Rongzhong, Li Yongyong, Ran Haitao, Shang Tingting
• Journal: Neurotoxicity research (Neurotox Res) Vol. 39 Issue 4 Pg. 1293-1299 (Aug 2021) ISSN: 1476-3524 [Electronic] United States
• PMID: 33999358 (Publication Type: Journal Article, Observational Study)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Antigens, CD
• Biomarkers
• Cell Adhesion Molecules
• ICAM3 protein, human

Topics

• Aged
• Antigens, CD (blood)
• Biomarkers (blood)
• Brain Ischemia (blood, diagnosis)
• Cell Adhesion Molecules (blood)
• Female
• Follow-Up Studies
• Humans
• Ischemic Stroke (blood, diagnosis)
• Male
• Middle Aged
• Severity of Illness Index
• Time Factors
• Treatment Outcome