Chitinase-3-Like Protein 1

A lectin that binds CHITIN, but lacks chitinase activity. It may be involved in tissue remodeling and cellular responses to the environment, including the response of type 2 HELPER T-CELLS to INFLAMMATION and sensitization to ALLERGENS. Mutations in the CHI3L1 gene are associated with ASTHMA.

Also Known As:

CGP-39 Protein; CHI3L1 Protein; Cartilage Glycoprotein 39; GP-39 Protein; YLK-40 Protein; CGP 39 Protein; Chitinase 3 Like Protein 1; GP 39 Protein; Glycoprotein 39, Cartilage; YLK 40 Protein

Networked: 160 relevant articles (3 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zetterberg, Henrik: 8 articles (11/2021 - 01/2016)
2.	Szepietowski, Jacek C: 7 articles (02/2022 - 07/2015)
3.	Blennow, Kaj: 7 articles (10/2021 - 01/2016)
4.	Matusiak, Łukasz: 6 articles (01/2019 - 07/2015)
5.	Salomon, Joanna: 6 articles (01/2019 - 07/2015)
6.	Nowicka-Suszko, Danuta: 5 articles (02/2022 - 07/2015)
7.	Fagan, Anne M: 4 articles (01/2021 - 09/2015)
8.	Ix, Joachim H: 3 articles (07/2022 - 01/2019)
9.	Shlipak, Michael G: 3 articles (07/2022 - 01/2019)
10.	Elias, Jack A: 3 articles (03/2022 - 01/2014)

Related Diseases

1.	Fibrosis (Cirrhosis) 05/20/2018 - "[Diagnostic value of serum chitinase-3-like protein 1 in chronic liver disease of significant fibrosis and cirrhosis]." 01/01/2023 - "This study aimed to compare the predictive value of chitinase-3-like protein 1 (CHl3L1) and other non-invasive biomarkers, as well as to establish a novel non-invasive diagnostic model for assessing the risk of significant fibrosis in NAFLD. " 01/01/2007 - "The aim of the study was to evaluate the serum concentration of YKL-40 (human cartilage glycoprotein-39) in the assessment of fibrosis stage in children compared to biopsy and prior to antiviral treatment for chronic hepatitis B. " 01/20/2023 - "Objective: To investigate the efficacy of chitinase-3-like protein 1 (CHI3L1) and Golgi protein 73 (GP73) in the diagnosis of cirrhosis and the dynamic changes of CHI3L1 and GP73 after HCV clearance in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral drugs (DAAs). " 04/01/2008 - "Our aim was to evaluate the diagnostic accuracy of hyaluronic acid (HA), FIBROSpect II (FS-II), and YKL-40 (chondrex, human cartilage glycoprotein-39) in various clinically important categories of fibrosis, and further correlate these serum markers with digital quantification of fibrosis (DQF) and Ishak stages. "
2.	Chronic Hepatitis C 01/01/2021 - "The goal of the present study was to evaluate the effects of HCV eradication on liver stiffness measurements (LSMs), aspartate aminotransferase/platelet ratio index (APRI) scores, fibrosis-4(FIB-4) scores, chitinase-3-like protein 1 (CHI3L1) levels and Golgi protein 73 (GP73) levels in patients with chronic hepatitis C (CHC). " 01/20/2023 - "Objective: To investigate the efficacy of chitinase-3-like protein 1 (CHI3L1) and Golgi protein 73 (GP73) in the diagnosis of cirrhosis and the dynamic changes of CHI3L1 and GP73 after HCV clearance in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral drugs (DAAs). "
3.	Inflammation (Inflammations) 01/01/2018 - "Chitinase-3-like protein 1 ameliorates atherosclerotic responses via PPARδ-mediated suppression of inflammation and ER stress." 01/01/2022 - "Furthermore, FBDS treatment decreased the expression of transforming growth factor-β1 and chitinase-3-like protein 1. In conclusion, the results demonstrated that treatment with FBDS inhibited LPS-induced inflammation in RAW264.7 and BMDM cells. " 12/01/2021 - "Chitinase-3-like protein 1 (CHI3L1) has been introduced as a marker of inflammation in different diseases, which can promote cell proliferation and differentiation. " 01/01/2020 - "Using high-throughput label-free proteomics, we found that inflammation-related autocrine factor Chitinase-3-like protein 1 (CHI3L1, or YKL-40) is highly expressed in the NP cells during degeneration. " 01/01/2017 - "Chitinase-3-like protein 1 (YKL-40) plays a role in inflammation. "
4.	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 08/29/2022 - "We quantified galactosaminoglycans (GAAGs), oligomeric cartilage matrix protein (COMP), and human cartilage glycoprotein 39 (YKL-40) in blood obtained from juvenile idiopathic arthritis (JIA) before and during 2-year treatment with etanercept (ETA), as potential biomarkers of cartilage extracellular matrix (ECM) dysfunction and indicators of efficacy of biologic therapy. "
5.	Asthma (Bronchial Asthma) 01/01/2022 - "Many studies have shown that chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is associated with asthma. " 01/12/2015 - "YKL-40 is also called chitinase-3-like-1 (CHI3L1) protein and may be a marker for asthma. " 12/01/2018 - "The aim of this study was to estimate the serum levels of human chitinase-3-like protein 1 (YKL40) and periostin in a group of Egyptian children with asthma during acute asthma exacerbation and in stable asthmatics compared with healthy control, and to correlate these findings with the severity of asthma. " 01/01/2021 - "We previously described serum periostin and chitinase-3-like protein 1 (YKL-40) as useful markers for asthma-COPD overlap (ACO). " 01/01/2019 - "To evaluate serum periostin, a type 2 biomarker, and serum chitinase-3-like protein 1 (YKL-40), a useful biomarker for COPD, in Japanese patients with asthma, ACO, or COPD, and investigate the role of these biomarkers in identifying ACO. "

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Related Therapies and Procedures

1.	Biological Therapy
2.	Phototherapy (Light Therapy)
3.	Continuous Renal Replacement Therapy
4.	Therapeutics
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)