Pathogen-Associated Molecular Pattern Molecules

Pathogens' molecules with specific sequence patterns that are recognized by PATTERN RECOGNITION RECEPTORS. They include microbial DNA, double-stranded RNA, surface glycoproteins, lipopolysaccharides, peptidoglycans, and lipoteichoic acid.

Also Known As:

Molecules, Pathogen-Associated Molecular Pattern; PAMPs; Pathogen-Associated Molecular Patterns; Pathogen Associated Molecular Pattern; Pathogen Associated Molecular Pattern Molecules; Pathogen Associated Molecular Patterns; PAMP; Pathogen-Associated Molecular Pattern

Networked: 1720 relevant articles (22 outcomes, 77 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Biological Factors: 2472
- Pathogen-Associated Molecular Pattern Molecules: 1720

Experts

1.	Zipfel, Cyril: 23 articles (09/2021 - 08/2005)
2.	Gale, Michael: 14 articles (01/2018 - 02/2007)
3.	Brown, Gordon D: 10 articles (01/2021 - 01/2006)
4.	Zhou, Jian-Min: 8 articles (01/2021 - 04/2009)
5.	Zhang, Jie: 7 articles (11/2021 - 09/2010)
6.	Nie, Pin: 7 articles (01/2021 - 04/2009)
7.	Li, Wei: 6 articles (01/2022 - 07/2009)
8.	Samanta, Mrinal: 6 articles (08/2021 - 03/2014)
9.	Wang, Ping: 6 articles (01/2021 - 07/2009)
10.	Gow, Neil A R: 6 articles (01/2020 - 08/2008)

Related Diseases

1.	Infections 01/01/2014 - "These results support a role for DCs in triggering the immune response to the IV through a mechanism similar to the phagocyte response to PAMPs with a central role for C3 in protection against mycobacterial infection. " 01/01/2021 - "A single cell may receive multiple signal inputs and we consider that multiple TLRs are likely triggered during infection by multiple PAMPs that, in turn, might be involved in infection driven megakaryocytopoiesis, and the present study provide the evidence for the megakaryocytic effects of TLRs co-stimulation." 01/01/2021 - "In this review, we discuss the role of each RIPK in host responses to bacterial and viral pathogens, with a focus on studies that have used pathogen infection models rather than artificial stimulation with purified pathogen associated molecular patterns. " 09/10/2015 - "The present study assessed nine reference genes in bovine kidney cells under conditions of BVDV-1 infection, incubation with pathogen-associated molecular patterns, and co-incubation with BAY117085, a pharmacological inhibitor of the NF-κB signaling pathway. " 02/01/2014 - "Genetic studies revealed that Arabidopsis ACIP family members are required for both pathogen-associated molecular pattern (PAMP)-triggered immunity and AvrBsT-triggered ETI during Pseudomonas syringae pathovar tomato DC3000 (Pst DC3000) infection. "
2.	Porcine Reproductive and Respiratory Syndrome (PRRS) 10/10/2020 - "Particularly effective may be the combination of multiple PAMPs that activate different PRRs, which occurs with natural pathogens. " 10/01/2023 - "PRRs are expressed mainly on immune cell surfaces and recognize at least one PAMP. " 06/01/2023 - "Despite PRRs and their co-receptor BAK1 were necessary for both PAMP induced immune response and root growth inhibition, bik1 mutant only showed impaired defense response but relatively normal root growth inhibition, suggesting BIK1 acts differently in these two biological processes." 03/25/2023 - "Recognition of PAMPs or DAMPs through PRRs activates the cellular autonomous defence mechanism, which orchestrates the cell responses to resolve specific insults at the single cell level. " 03/25/2023 - "Engagement of PRRs in recognition of PAMPs or DAMPs is one of the processes that initiates cellular stress. "
3.	Neoplasms (Cancer) 01/01/2021 - "Because bacteria are abundant in pathogen-associated molecular patterns that can effectively activate the immune cells even in the tumor immunosuppressive microenvironment, they are capable of enhancing the specific immune recognition and elimination of tumor cells. " 01/01/2021 - "In vitro and in vivo experiments proved that PSMs can generate heat for the direct elimination of tumors and release a series of pathogen-associated molecular patterns and adjuvants for immune stimulation under light irradiation. " 01/01/2020 - "Prolonged activation of TLR by these endogenous PAMPs leads to chronic inflammatory insults to the body and which in turn alters the proliferative patterns of the cells, which ultimately leads to the development of cancer. " 01/01/2020 - "Plasmacytoid DCs (pDCs) and γδT cells are both critical players in immunosurveillance against pathogens and cancer due to their ability to sense microbes and cell stress through recognition of pathogen-associated molecular patterns or altered metabolism [phosphoantigens (PAgs)]. " 06/14/2018 - "Emerging data are however challenging this view, indicating that the cross-presenting machinery in DCs is suboptimally activated by direct PAMP recognition, and that endogenous inflammatory factors are the main drivers of DC-mediated cross-presentation within the tumor. "
4.	Wounds and Injuries (Trauma) 01/01/2013 - "PAMP was very effective in promoting reepithelialization and angiogenesis, whereas treatment with stem/progenitor cells alone resulted in less wound contraction. " 08/22/2023 - "Reduced Bioactive Microbial Products (Pathogen-Associated Molecular Patterns) Contribute to Dysregulated Immune Responses and Impaired Healing in Infected Wounds in Mice with Diabetes." 01/01/2019 - "Infectious and sterile injuries cause the release of PAMPs and DAMPs. " 01/01/2016 - "On the other hand, MSCs represent "targets" during the pathophysiological conditions after severe trauma, when excessively generated inflammatory mediators, complement activation factors, and damage- and pathogen-associated molecular patterns challenge MSCs and alter their functionality. " 01/01/2016 - "We induced an exacerbated and prolonged inflammatory state in these wounds with the combination of trauma-related stimulators of pathogen-associated molecular patterns from heat-killed Pseudomonas aeruginosa and damage-associated molecular patterns from a dermal homogenate. "
5.	Inflammation (Inflammations) 08/01/2012 - "This specificity of particular PAMPs and their newly defined receptors provided a common ground between pharmacologists and immunologists for the study of inflammation. " 10/19/2023 - "They recognise certain molecules known as pathogen-associated molecular pattern on a pathogen and release chemicals that causes inflammation. " 01/01/2023 - "We propose that macrophages use eructophagy to release processed PAMPs/DAMPs to amplify local inflammation." 01/01/2023 - "Herein, we show that extracellular vesicles from plasma (pEVs) play a relevant role in the control of inflammation by counteracting PAMP-induced macrophage activation. " 01/01/2023 - "NLRP3 is activated by a diverse range of inflammation-instigating signals known as pathogen associated molecular patterns and danger associated molecular patterns. "

Related Drugs and Biologics

1.	Pathogen-Associated Molecular Pattern Molecules
2.	Vaccines
3.	Cytokines
4.	Antigens
5.	Toll-Like Receptors (Toll-Like Receptor)
6.	Ligands
7.	Pattern Recognition Receptors
8.	Chemokines
9.	lipoteichoic acid
10.	Interleukins

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Ligation
4.	Drug Therapy (Chemotherapy)
5.	Punctures