Research progress of pattern recognition receptors in red swamp crayfish (Procambarus clarkii).

Abstract

Though Procambarus clarkii (red swamp crayfish) is a lower invertebrate, it has nonetheless developed a complex innate immune system. The crayfish farming industry has suffered considerable economic losses in recent years as a consequence of bacterial and viral diseases. Hence, perhaps the most effective ways to prevent microbial infections in P. clarkii are to examine and elucidate its innate immunity. The first step in the immune response is to recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs). PRRs are expressed mainly on immune cell surfaces and recognize at least one PAMP. Thence, downstream immune responses are activated and pathogens are phagocytosed. To date, the PRRs identified in P. clarkii include Toll-like receptors (TLRs), lectins, fibrinogen-related proteins (FREPs), and β-1,3-glucan-binding proteins (BGRPs). The present review addresses recent progress in research on PRRs and aims to provide guidance for improving immunity and preventing and treating infectious diseases in P. clarkii.

• Authors: Yanlong Gu, Lei Zhu, Xinru Wang, Hao Li, Libo Hou, Xianghui Kong
• Journal: Fish & shellfish immunology (Fish Shellfish Immunol) Vol. 141 Pg. 109028 (Oct 2023) ISSN: 1095-9947 [Electronic] England
• PMID: 37633345 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2023 Elsevier Ltd. All rights reserved.

Chemical References

• Receptors, Pattern Recognition
• Toll-Like Receptors

Topics

• Animals
• Astacoidea
• Receptors, Pattern Recognition (genetics)
• Immunity, Innate
• Toll-Like Receptors (metabolism)
• Bacteria (metabolism)