poliferprosan 20 drug combination carmustine (Gliadel)

03/01/2008 - "Preclinical and clinical studies have proven the safety and efficacy of Gliadel in the management of glioblastoma. "
01/01/2020 - "Gliadel placement in glioblastoma resection, particularly with concurrent chemoradiation, has demonstrated an improvement in survival. "
08/01/2012 - "Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastomas."
08/01/2012 - "Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastoma."
04/15/2006 - "Based on Phase I/II clinical trials, the Phase III Randomized Evaluation of CED of IL13-PE Compared to Gliadel Wafer with Survival Endpoint Trial (also known as the PRECISE Trial) in patients with initial recurrence of glioblastoma multiforme has recently been completed. "

02/01/2009 - "Future trials are required to verify that inhibition of tumor AGT levels by O6-BG results in increased efficacy of Gliadel wafers without added toxicity."
10/01/2007 - "Because several randomized controlled trials (RCTS) investigating the safety and efficacy of Gliadel are available, the Neuro-oncology Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care decided that a systematic review of the evidence was necessary. "
02/18/2022 - "The median overall survival (OS) of patients receiving low-dose Cerebraca wafer was 12 months in the group with >25% wafer coverage of the resected tumor, which is longer than OS duration in previously published studies (Gliadel wafer, 6.4 months). "
04/01/2020 - "Adjuvant autologous dendritic cells pulsed with tumor-lysate following resection and Gliadel Wafer placement is safe, elicits modest immunogenicity and shows similar clinical outcomes in patients who had DC vaccination in previous studies."
01/01/2016 - "The mean time to tumor progression (n = 7) and death (n = 5) after Gliadel wafer implantation was 2.5 and 2.9 years, respectively. "

01/01/2016 - "The goal of this study was to assess the safety and efficacy of Gliadel wafers in patients with metastatic brain tumors. "
01/01/2022 - "This study aimed to simulate the drug concentration in the cavity after drug releases from Gliadel wafers into the brain tumor by a two-dimensional simulation. "
08/27/1999 - "The present study provides a quantitative examination on the working principle of Gliadel wafer for the treatment of brain tumors."
01/01/2016 - "Gliadel wafers were used in 14 patients with metastatic brain tumors during the period reviewed. "
01/01/2016 - "We retrospectively reviewed the University of Washington experience with Gliadel wafers for metastatic brain tumors between 2000 and 2015. "

01/01/2022 - "This study confirmed the 2- and 3-year OS of Japanese malignant glioma patients with varied backgrounds after Gliadel implant. "
09/15/2021 - "In this postmarketing surveillance study, all patients who received Gliadel placement for malignant glioma surgeries from its market launch (January 9, 2013) to July 10, 2013 were enrolled from 229 institutions using a central registration system. "
03/01/2007 - "This study explores (1)H MRSI as a means to assess peri-tumoral tissue response post-resection and Gliadel((R)) implantation in patients with high-grade gliomas. "
03/01/2006 - "Gliadel wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial."
01/01/2004 - "Randomized trials have demonstrated Gliadel improves survival for appropriately selected patients with newly diagnosed malignant glioma. "

10/01/2008 - "In our experience, use of Gliadel wafer was not associated with an increase in perioperative morbidity after surgical treatment of malignant astrocytoma."
08/01/2013 - "Prolonged survival associated with the use of intraoperative carmustine (Gliadel) in a paediatric patient with recurrent grade III astrocytoma."
10/01/2008 - "A total of 288 (28%) received Gliadel wafer (250 glioblastoma multiforme (GBM), 38 anaplastic astrocytoma/anaplastic oligodendroglioma (AA/AO), 166 primary resection, 122 revision resection). "
04/01/2020 - "Twenty-eight patients received Gliadel Wafers and DC vaccination: 11 newly diagnosed (8 glioblastoma [GBM], 2 anaplastic astrocytoma [AA], and 1 anaplastic oligodendroglioma [AO]) and 17 recurrent (15 GBMs, 1 AA, and 1 AO) high grade gliomas. "
05/01/2005 - "A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme."