Temozolomide (Temodar)

A dacarbazine derivative that is used as an alkylating antineoplastic agent for the treatment of MALIGNANT GLIOMA and MALIGNANT MELANOMA.

Also Known As:

Temodar; 8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one; CCRG 81045; CCRG-81045; M&B 39831; M&B-39831; Methazolastone; NSC 362856; NSC-362856; TMZ-Bioshuttle; TMZA-HE; Temodal; Temozolomide Hexyl Ester; CCRG81045; M&B39831; NSC362856; TMZ Bioshuttle

Networked: 6805 relevant articles (722 outcomes, 1489 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Weller, Michael: 89 articles (11/2022 - 03/2002)
2.	Wick, Wolfgang: 73 articles (01/2022 - 03/2002)
3.	Stupp, Roger: 64 articles (01/2022 - 03/2002)
4.	Reardon, David A: 57 articles (11/2022 - 02/2003)
5.	Brandes, Alba A: 48 articles (04/2022 - 01/2002)
6.	Sarkaria, Jann N: 45 articles (04/2022 - 09/2007)
7.	van den Bent, Martin J: 45 articles (01/2022 - 12/2003)
8.	Gilbert, Mark R: 44 articles (12/2021 - 10/2002)
9.	Friedman, Henry S: 44 articles (05/2020 - 09/2002)
10.	Wen, Patrick Y: 43 articles (05/2022 - 11/2006)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 01/01/2020 - "Temozolomide (TMZ) is one of the most commonly used clinical drugs for glioblastoma (GBM) treatment, but its drug sensitivity needs to be improved. " 07/15/1994 - "Temozolomide was also highly effective against intracerebral implants of the U251 and SF-295 glioblastomas. " 10/05/2022 - "Epigenetic silencing of the DNA repair gene MGMT has proven utility as a positive predictor of the therapeutic efficacy of the alklyating drug temozolomide (TMZ) in tumours such as glioblastoma multiforme. " 12/01/2017 - "Temozolomide is the first chemotherapeutic agent proven effective for patients with newly diagnosed glioblastoma. " 03/01/2020 - "In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). "
2.	Glioma (Gliomas) 06/15/2019 - "We identified hybrid compounds 1d and 1e to be remarkably more potent against glioma and more efficient in decreasing invasive cell properties than temozolomide and endowed with chemical and plasma stability. " 10/01/2000 - "Temozolomide is a novel methylating agent with proven efficacy against malignant gliomas (MGs) after systemic administration but with dose-limiting myelotoxicity. " 10/01/2019 - "Efficacy of initial temozolomide for high-risk low grade gliomas in a phase II AINO (Italian Association for Neuro-Oncology) study: a post-hoc analysis within molecular subgroups of WHO 2016." 09/01/2014 - "A phase II trial was performed to evaluate the efficacy of a dose-dense, 7 days on/7 days off schedule of temozolomide for patients with recurrent high-grade gliomas (HGG). " 05/01/2008 - "Even though past studies have suggested efficacy of nitrosourea drugs in patients with high-grade glioma and temozolomide has recently been shown significantly to be beneficial, no conclusive comparisons between these agents have been published. "
3.	Neoplasms (Cancer) 01/01/2013 - "For astrocytic tumors, MGMT is associated with a better prognosis and an improved response to temozolomide, and for all glial tumors, mutations in the IDH1 gene are possibly the most potent of good prognostic markers. " 11/01/2008 - "The resistance of tumors characterized by unmethylated MGMT promoter may be overcome by near continuous temozolomide administration, which is probably most effective with a 5/7-day schedule. " 01/01/2020 - "Despite a variety of advances in the understanding of GBM cancer biology during recent decades, very few of them were applied into treatment, and the survival rate of GBM patients has not been improved majorly due to the low chemosensitivity to temozolomide (TMZ) or low radiosensitivity. " 01/01/2020 - "After a 7.5 year-long complete remission, the tumor recurred locally, was treated by GTR, and responded to temozolomide treatment. " 04/01/2009 - "The marked improvement in clinical state of the first 2 patients accompanied by radiological evidence of tumor shrinkage in all patients demonstrates the potential use of temozolomide in treating aggressive pituitary macroadenomas. "
4.	Brain Neoplasms (Brain Tumor) 02/10/2014 - "To better understand the efficacy of temozolomide in the treatment of brain metastases, we carried out a review of 21 published clinical trials to determine whether temozolomide would benefit patients with brain metastases from solid tumours. " 01/01/2022 - "Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture." 08/01/2011 - "Temozolomide is an effective treatment for seizure control in patients with brain tumors." 01/15/2002 - "Moreover, temozolomide readily crosses the blood-brain barrier and may consequently be effective in patients with brain metastases. " 05/01/2009 - "In this preliminary study, oral temozolomide shows promising results on recurrent embryonal brain tumors in children. "
5.	Melanoma (Melanoma, Malignant) 11/28/2006 - "Clinical trials have shown temozolomide to be an effective agent for treatment of malignant melanoma. " 04/01/2023 - "Longer survival was seen with DM-CHOC-PEN in a C57BL murine model relative to temozolomide and saline-treated controls, supporting the development of clinical trials assessing the efficacy of DM-CHOC-PEN as treatment for metastatic melanoma." 10/17/2017 - "The present study used a previously-established patient-derived orthotopic xenograft (PDOX) nude mouse model of BRAF V600E-mutant melanoma to determine the efficacy of rMETase in combination with a first-line melanoma drug, temozolomide (TEM). " 01/01/2015 - "Enhanced antitumor efficacy of a novel oncolytic adenovirus combined with temozolomide in the treatment of melanoma in vivo." 03/27/2004 - "Temozolomide (TMZ) displays efficacy for the treatment of metastatic melanoma. "

Related Drugs and Biologics

1.	Alkylating Agents
2.	Bevacizumab (Avastin)
3.	DNA (Deoxyribonucleic Acid)
4.	Capecitabine (Xeloda)
5.	Irinotecan (Camptosar)
6.	Dacarbazine (DIC)
7.	Methyltransferases
8.	Carmustine (FIVB)
9.	Lomustine (CCNU)
10.	Procarbazine (Matulane)

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Chemoradiotherapy
5.	Salvage Therapy