Band-Shaped Corneal Dystrophy

A hereditary band-shaped opacity of the cornea , affecting the pupil and palpebral fissure (space between eyelids). The central region is more dense and contains grey, grainy elements. OMIM: 217500

Also Known As:

Networked: 124 relevant articles (10 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Hyphema
3.	Corneal Opacity
4.	Uveitis
5.	Cataract (Cataracts)

Experts

1.	Thorne, Jennifer E: 4 articles (01/2022 - 09/2008)
2.	Chang, Yuh-Shin: 2 articles (01/2022 - 01/2021)
3.	Foster, C Stephen: 2 articles (01/2022 - 11/2012)
4.	Jabs, Douglas A: 2 articles (01/2022 - 11/2012)
5.	Jan, Ren-Long: 2 articles (01/2022 - 01/2021)
6.	Kempen, John H: 2 articles (01/2022 - 11/2012)
7.	Levy-Clarke, Grace A: 2 articles (01/2022 - 11/2012)
8.	Nussenblatt, Robert B: 2 articles (01/2022 - 11/2012)
9.	Pistilli, Maxwell: 2 articles (01/2022 - 11/2012)
10.	Pujari, Siddharth S: 2 articles (01/2022 - 11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Band-Shaped Corneal Dystrophy:

1.	Edetic Acid (EDTA)FDA Link 03/01/2012 - "Surgical treatment using EDTA is safe and effective treatment for band keratopathy." 04/01/2010 - "The combination of EDTA chelation, PTK, and AMT is safe and effective for the treatment of band keratopathy." 06/01/2023 - "Therefore, the purpose of this study was to determine the safe dose range of EDTA for calcific band keratopathy surgery and its toxic effects on rabbit eyes. " 01/01/2022 - "The long-term results of 5 patients (5 eyes) with symptomatic band keratopathy with a follow-up period of at least 6 months, in whom 2% EDTA was chelated on the affected eye in the study period from April 2018 to March 2021, were retrospectively evaluated. " 12/01/2023 - "In situations where sterile sources of Na 2 EDTA are unavailable, potassium EDTA may provide a convenient and equally effective method of treatment for band keratopathy."
2.	CalciumIBA 10/01/2022 - "There are two types of corneal calcium deposition, one is calcific band keratopathy and another is calcareous degeneration. " 07/01/2014 - "The patient was euthanized a short while after diagnosis due to reasons unrelated to the eyes and histologic examination of the corneas revealed subepithelial calcium and vascularization, consistent with calcific band keratopathy. " 03/01/1993 - "In the patients with band keratopathy we removed the calcium deposits mechanically and then used masking fluids to obtain a smooth surface. " 04/01/1988 - "In late stages the cornea sometimes developed a band of calcium precipitates beneath the basal epithelial cells (band keratopathy). " 09/01/1975 - "A simple method for treating band keratopathy consists of scraping the cornea vigorously with a No. 15 scalped blade until the superficial calcium has been removed."
3.	Silicone OilsIBA 09/01/2021 - "On examination, conjunctiva congestion, band keratopathy, silicone oil emulsification, and limbus neovascularization were found. " 11/01/1993 - "Band keratopathy recurred in nine eyes (8%) within 2 to 30 months (mean 12 months) of surgery, with silicone oil responsible in five eyes. " 10/01/1990 - "Band keratopathy from emulsified silicone oil." 04/01/1985 - "Changes induced by silicone oil include band keratopathy, thinning, and endothelial damage. " 09/11/2022 - "Both band keratopathy and corneal decompensation were caused by severe anterior segment trauma and were not related to the silicone oil contact with the cornea. "
4.	Citric Acid (Citrate)FDA LinkGeneric 09/01/1981 - "In the citrate-treated eyes there was a significantly reduced incidence of band keratopathy (17%) but an increased incidence of hyphema (100%). "
5.	prednisolone acetateFDA LinkGeneric 11/01/2023 - "The patient's condition rapidly improved with the administration of prednisolone acetate and autologous serum, with significant resolution of the transparent band keratopathy within 5 weeks of treatment initiation and subsequent complete visual recovery. "
6.	AcidsIBA 01/01/2019 - "Five eyes had visually significant central band keratopathy that required treatment with disodium ethylenediaminetetracetic acid (EDTA) chelation or phototherapeutic keratectomy. " 06/01/2004 - "To determine the etiologies and management of calcific band keratopathy (CBK), and assess the results and long-term follow-up after ethylenediamine-tetraacetic acid (EDTA) chelation. " 08/01/2018 - "To report an unusual presentation of iridocorneal endothelial (ICE) syndrome associated with band keratopathy and its management with ethylenediamine-tetraacetic acid (EDTA) chelation and Descemet membrane endothelial keratoplasty (DMEK). " 07/01/2006 - "The surgical treatment of band keratopathy usually consists of abrasion of the corneal epithelium followed by removal of the subepithelial calcium deposits by means of an ethylenediamine-tetraacetic acid (EDTA) solution. "
7.	Vitamin DFDA LinkGeneric 07/01/1954 - "Band keratopathy in vitamin D intoxication; report of a case." 01/01/1992 - "We describe a hypoparathyroid patient with vitamin D intoxication who developed painful periarticular calcinosis, nephrocalcinosis with hypertension and chronic renal failure in addition to band keratopathy and hearing loss. " 01/01/1987 - "An experimental band keratopathy was produced in rabbits by local injection of egg albumin and vitamin D intoxication. "
8.	SolutionsIBA 10/01/2021 - "To compare 3 methods for creating ethylenediaminetetraacetic acid (EDTA) solution using readily available Vacutainer tubes for the treatment of band keratopathy. " 07/01/2006 - "In three patients (four eyes) with long-standing band keratopathy, the epithelium was detached with a 19% ethanol solution and placed gently toward the limbus, a method also used in laser-assisted subepithelial keratectomy (LASEK). " 07/01/2006 - "The surgical treatment of band keratopathy usually consists of abrasion of the corneal epithelium followed by removal of the subepithelial calcium deposits by means of an ethylenediamine-tetraacetic acid (EDTA) solution. " 07/01/1987 - "Band keratopathy developed rapidly in two patients following uneventful phacoemulsification and intraocular lens implantation using BSS Plus (balanced salt solution enriched with glutathione, bicarbonate, and glucose) infusion and Viscoat (chondroitin sulfate-sodium hyaluronate), which was left in the anterior chamber at the conclusion of the procedure. "
9.	SaltsIBA 01/01/1995 - "Band keratopathy, calcium salts in Bowman's membrane, is the most classic form of corneal calcification seen in clinical practice. " 11/01/2011 - "Calcific band keratopathy (CBK) is a degenerative condition resulting in the deposition of calcium salts in the superficial layers of the cornea and causing significant visual disturbance and pain of the affected eye. " 07/01/1987 - "Band keratopathy developed rapidly in two patients following uneventful phacoemulsification and intraocular lens implantation using BSS Plus (balanced salt solution enriched with glutathione, bicarbonate, and glucose) infusion and Viscoat (chondroitin sulfate-sodium hyaluronate), which was left in the anterior chamber at the conclusion of the procedure. "
10.	Retinaldehyde (Retinal)IBA 12/01/1994 - "Visual function, in these young patients, may be compromised by severe complications such as band keratopathy, posterior synechiae, cataract, glaucoma, and retinal oedema. " 07/01/2014 - "Cystoid macula edema, epiretinal membrane, retinal ischemia, cataract, glaucoma, and band keratopathy were complications noted in the follow-up period. " 01/01/2018 - "Biallelic mutations in the gene SLC4A4 (Solute Carrier Family 4 Member 4) cause protean manifestations in children that include proximal retinal tubular acidosis, developmental delay, band keratopathy, and glaucoma. "

Therapies and Procedures

1.	Excimer Lasers 04/01/2000 - "Excimer laser PTK is a safe and effective outpatient treatment and should be used as initial treatment for band keratopathy." 11/01/1993 - "Excimer laser PTK is a safe and effective outpatient treatment for band keratopathy." 01/01/2021 - "The band keratopathy was treated via PTK using the Mel-90 excimer laser with an optical treatment zone of 7.0 mm and ablation depth of 120 μm. " 07/01/2011 - "Recent use of combination treatments such as chelation, excimer laser, and amniotic membrane transplantation has renewed interest in the management of cases with band keratopathy in order to achieve faster epithelial healing and better postoperative outcomes. " 11/01/1993 - "A series of 122 eyes with band keratopathy was treated by excimer laser phototherapeutic keratectomy (PTK), with a mean follow up of over 12.3 months (range 3 to 60 months). "
2.	Transplantation 05/01/2001 - "Amniotic membrane transplantation represents a safe and effective method to restore a stable corneal epithelium in eyes after primary surgical removal of band keratopathy arising from ocular causes." 05/01/2001 - "Amniotic membrane transplantation after the primary surgical management of band keratopathy." 07/01/2011 - "Recent use of combination treatments such as chelation, excimer laser, and amniotic membrane transplantation has renewed interest in the management of cases with band keratopathy in order to achieve faster epithelial healing and better postoperative outcomes. " 05/01/2001 - "To determine the safety and efficacy of amniotic membrane transplantation to restore and maintain a stable corneal epithelium and reduce ocular surface pain after surgical removal of band keratopathy arising from ocular causes. " 09/01/2008 - "Novel therapeutic approach in the management of band keratopathy using amniotic membrane transplantation with fibrin glue."
3.	Keratectomy 10/01/2020 - "The goal of this study was to investigate the clinical outcomes of transepithelial phototherapeutic keratectomy (transepithelial PTK) for the treatment of severe band keratopathy. " 10/01/2020 - "Transepithelial phototherapeutic keratectomy for the treatment of severe band keratopathy." 06/01/2014 - "The patient declined the surgical intervention options of chelation, lamellar keratectomy, and phototherapeutic keratectomy to treat the band keratopathy. " 02/01/2006 - "Management of band keratopathy with excimer phototherapeutic keratectomy." 03/01/2003 - "To report on the outcome of excimer phototherapeutic keratectomy (PTK) in the management of band keratopathy. "
4.	Corneal Transplantation (Keratoplasty) 08/01/2010 - "A 55-year-old woman underwent autologous keratoplasty because of band keratopathy and corneal decompensation of the left eye. " 11/27/2023 - "Subsequent corneal interventions included chelation of calcific band keratopathy (n = 1, 7%), lamellar keratoplasty (n = 1, 7%), penetrating keratoplasty (n = 2, 18%), keratoprosthesis (n = 1, 7%), and rigid contact lens wear (n = 4, 27%). " 01/01/1990 - "Corneal smoothing using an immersion fluid can be used after lamellar keratoplasty or to remove superficial pathological structures such as band keratopathy and superficial scars." 08/01/2018 - "Atypical Presentation of Iridocorneal Endothelial Syndrome With Band Keratopathy but No Corneal Edema Managed With Descemet Membrane Endothelial Keratoplasty." 01/01/2021 - "After adjusting for potential confounders, including diabetes mellitus, keratoconjunctivitis sicca, corneal transplantation, ocular blunt trauma, corneal dystrophy, and band keratopathy, AKC patients were 1.36 times more likely to develop RCE than controls (adjusted HR, 1.36; 95% CI = 1.19-1.54; p < 0.05). "
5.	Slit Lamp 06/01/2015 - "A 70-year-old British white woman showed band keratopathy in the right eye and dense white lines and dots in her left cornea on slit-lamp examination. " 11/01/2013 - "A slit-lamp examination showed peripheral corneal band keratopathy and multiple white crystals in the anterior chamber. " 04/01/2016 - "Slit lamp examination revealed bilateral band keratopathy with quiescent anteriorchamber reaction, an intumescent cataract in the left eye, and dense posterior capsular opacity in the right eye. " 07/01/2019 - "Main outcome measures included Slit-lamp findings (1), CDVA (2), patients' complaints (3).The mean follow-up period was 44.0 ± 38.8 months (range: 1-156 months).We treated 376 granular corneal dystrophy (GCD) eyes, 238 band keratopathy (BK) eyes, 23 epithelium attachment disorder eyes, 16 gelatinous drop-like corneal dystrophy (GDLD) eyes, 13 lattice corneal dystrophy (LCD) eyes, and 48 eyes with other corneal diseases. "