Eye drops preservative as the cause of corneal band keratopathy in long-term pilocarpine hydrochloride treatment.

Abstract

The aim is to present a patient with severe bilateral corneal complications after long-term antiglaucoma treatment with 1% pilocarpine hydrochloride (Pilokarpin, Pliva, Zagreb, Croatia) and its management. A patient with narrow-angle glaucoma treated with 1% topical pilocarpine hydrochloride eye drops for the last twenty years complained of impaired vision, intermittent visual haloes and eye redness. Ophthalmologic examination showed bilateral band keratopathy, peripheral laser iridotomy, medicamentous myosis, brown nuclear cataract, and synchysis scintillans of his right eye. Band keratopathy was thought to have resulted from the presence of the preservative phenylmercuric nitrate in the pilocarpine hydrochloride eye drops. Treatment of the patient consisted of two separate procedures for both eyes, i.e. phaco trabeculectomy and six months later corneal procedure including abrasion of corneal epithelium followed by removal of the superficial stromal calcium deposits by means of a 3.75% ethylenediaminetetraacetic (EDTA) solution. After phaco trabeculectomy, visual acuity was 0.8 on both eyes. Bilateral visual improvement with visual acuity 1.0 was recorded after corneal treatment with EDTA. In conclusion, one must be aware of preservative complications in long-term topical use, such as band keratopathy that can be visually incapacitating. Surgical treatment using EDTA is safe and effective treatment for band keratopathy.

• Authors: Jasna Pavicić-Astalos, Valentina Lacmanović-Loncar, Ivanka Petric-Vicković, Dean Sarić, Zdravko Mandić, Tigrena Csik, Nikola Susić
• Journal: Acta clinica Croatica (Acta Clin Croat) Vol. 51 Issue 1 Pg. 107-11 (Mar 2012) ISSN: 0353-9466 [Print] Croatia
• PMID: 22920012 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ophthalmic Solutions
• Phenylmercury Compounds
• Preservatives, Pharmaceutical
• Pilocarpine
• phenylmercuric nitrate, basic

Topics

• Aged
• Corneal Diseases (chemically induced, surgery)
• Glaucoma, Angle-Closure (drug therapy)
• Humans
• Male
• Ophthalmic Solutions
• Phenylmercury Compounds (adverse effects)
• Pilocarpine (therapeutic use)
• Preservatives, Pharmaceutical (adverse effects)