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GSK621

an AMP-activated protein kinase activator; structure in first source

Networked: 10 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Azoles: 2199
    - Imidazoles: 152
      - GSK621: 10
  - Pyrimidines: 521
    - Pyrimidinones: 74
      - GSK621: 10

Experts

1.	Mondesir, Johanna: 3 articles (10/2023 - 06/2015)
2.	Sujobert, Pierre: 3 articles (01/2022 - 06/2015)
3.	Tamburini, Jerome: 3 articles (01/2022 - 06/2015)
4.	Lane, Andrew A: 2 articles (10/2023 - 01/2022)
5.	Sarry, Jean-Emmanuel: 2 articles (10/2023 - 01/2022)
6.	Bouscary, Didier: 2 articles (01/2022 - 06/2015)
7.	Grenier, Adrien: 2 articles (01/2022 - 06/2015)
8.	Lambert, Mireille: 2 articles (01/2022 - 06/2015)
9.	Poulain, Laury: 2 articles (01/2022 - 06/2015)
10.	Viollet, Benoit: 2 articles (01/2022 - 06/2015)

Related Diseases

1.	Wounds and Injuries (Trauma) 02/07/2017 - "These results suggest that targeted activation of AMPK by GSK621 ameliorates H2O2-induced osteoblast cell injuries."
2.	Inflammation (Inflammations) 01/01/2021 - "GSK621 blocked the effect of PRR on AMPK and YAP and improved CF inflammation and fibrosis. "
3.	Fibrosis (Cirrhosis) 01/01/2021 - "GSK621 blocked the effect of PRR on AMPK and YAP and improved CF inflammation and fibrosis. "
4.	Glioma (Gliomas) 01/01/2016 - "We summarized that GSK621 inhibits human glioma cells possibly via activating AMPK signaling. " 01/01/2016 - "Consequently, GSK621's cytotoxicity in glioma cells was also significantly attenuated by AMPKα knockdown or mutation. " 01/01/2016 - "Further studies showed that GSK621, at a relatively low concentration, significantly potentiated temozolomide (TMZ)'s sensitivity and lethality against glioma cells. " 01/01/2016 - "We showed that GSK621 was cytotoxic to human glioma cells (U87MG and U251MG lines), possibly via provoking caspase-dependent apoptotic cell death. " 01/01/2016 - "Here, we studied the anti-glioma cell activity by a novel AMP-activated protein kinase (AMPK) activator GSK621. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2022 - "Using the direct AMPK activator GSK621, we show that the unfolded protein response (UPR) is activated by AMPK in acute myeloid leukemia (AML) cells. " 06/09/2015 - "Here, we report that the specific AMPK agonist GSK621 selectively kills acute myeloid leukemia (AML) cells but spares normal hematopoietic progenitors. " 07/01/2016 - "We report the therapeutic potential of GSK621, an AMP-activated protein kinase (AMPK) agonist, in acute myeloid leukemia (AML). "

Related Drugs and Biologics

1.	Temozolomide (Temodar)
2.	AMP-Activated Protein Kinases
3.	Proteins (Proteins, Gene)
4.	Tetraspanins
5.	TOR Serine-Threonine Kinases
6.	Caspase 3 (Caspase-3)
7.	Mitogen-Activated Protein Kinase Kinases (MEKs)
8.	Caspases
9.	Messenger RNA (mRNA)
10.	4- hydroxy- 3- (4- (2- hydroxyphenyl)phenyl)- 6- oxo- 7H- thieno(2,3- b)pyridine- 5- carbonitrile

Related Therapies and Procedures

1.	Oral Administration