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CPSI-1306

inhibits macrophage migration inhibitory factor

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - CPSI-1306: 4
  - Oxazines: 9
    - Morpholines: 6
      - CPSI-1306: 4

Experts

1.	Satoskar, Abhay R: 3 articles (01/2020 - 07/2010)
2.	Pruitt, James: 2 articles (09/2014 - 07/2010)
3.	Sielecki, Thais: 2 articles (09/2014 - 07/2010)
4.	Ahirwar, Dinesh K: 1 article (01/2020)
5.	Charan, Manish: 1 article (01/2020)
6.	Chatterjee, Nabanita: 1 article (01/2020)
7.	Das, Subhadip: 1 article (01/2020)
8.	Ganju, Ramesh K: 1 article (01/2020)
9.	Kaul, Kirti: 1 article (01/2020)
10.	Mishra, Sanjay: 1 article (01/2020)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 07/01/2010 - "Finally, oral administration of a small-molecule MIF antagonist, CPSI-1306, to outbred ICR mice following induction of NIDDM significantly lowered blood glucose levels in the majority of animals, which was also associated with a significant reduction in the levels of the proinflammatory cytokines IL-6 and TNF-alpha in the sera. "
2.	Neoplasms (Cancer) 09/01/2014 - "In addition to slowing the rate of tumor development, CPSI-1306 decreased the average tumor burden per mouse. " 09/01/2014 - "CPSI-1306 dramatically decreased the density of UVB-associated p53 foci in non-tumor-bearing skin while simultaneously decreasing the epidermal Ki67 proliferation index. " 01/01/2020 - "CPSI-1306 treatment of tumor-bearing mice significantly inhibited TNBC growth and pulmonary metastasis in a dose-dependent manner. " 01/01/2020 - "CPSI-1306 treatment also reduced the tumor growth and metastasis in orthotopic mouse models of mammary carcinoma. "
3.	Carcinogenesis 09/01/2014 - "To examine the effect of CPSI-1306 on squamous carcinogenesis, mice were exposed to UVB for 10 weeks, followed by CPSI-1306 treatment for 8 weeks. "
4.	Intervertebral Disc Degeneration 12/01/2023 - "To explore the treatment of intervertebral disc degeneration, we selected the small-molecular MIF inhibitor CPSI-1306. " 12/01/2023 - "CPSI-1306 had a therapeutic effect on intervertebral disc degeneration in the mouse model. " 12/01/2023 - "Macrophage migration inhibitory factor (MIF) promotes intervertebral disc degeneration through the NF-κB pathway, and the MIF inhibitor CPSI-1306 alleviates intervertebral disc degeneration in a mouse model."
5.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "CPSI-1306 treatment of tumor-bearing mice significantly inhibited TNBC growth and pulmonary metastasis in a dose-dependent manner. " 01/01/2020 - "CPSI-1306 treatment also reduced the tumor growth and metastasis in orthotopic mouse models of mammary carcinoma. "

Related Drugs and Biologics

1.	Cytokines
2.	Interleukin-6 (Interleukin 6)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Blood Glucose (Blood Sugar)
5.	Therapeutic Uses
6.	Macrophage Migration-Inhibitory Factors

Related Therapies and Procedures

1.	Oral Administration