Christian L Roth Selected Research

Type 2 Diabetes Mellitus (MODY)

1/2021	Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis.
1/2018	Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.
1/2018	A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents.
12/2017	Assessment of disturbed glucose metabolism and surrogate measures of insulin sensitivity in obese children and adolescents.
1/2012	Treatment with glucagon-like Peptide-1 agonist exendin-4 in a patient with hypothalamic obesity secondary to intracranial tumor.
6/2011	Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.

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Christian L Roth Research Topics

Disease

42	Obesity 04/2024 - 09/2005
29	Weight Loss (Weight Reduction) 12/2023 - 09/2005
24	Insulin Resistance 01/2021 - 03/2005
11	Body Weight (Weight, Body) 12/2023 - 01/2009
9	Weight Gain 03/2024 - 01/2011
7	Hyperphagia (Overeating) 03/2024 - 01/2011
7	Inflammation (Inflammations) 01/2019 - 09/2005
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2017 - 12/2007
6	Type 2 Diabetes Mellitus (MODY) 01/2021 - 06/2011
6	Non-alcoholic Fatty Liver Disease 06/2016 - 11/2008
6	Overweight 04/2012 - 03/2005
4	Morbid Obesity 03/2024 - 08/2009
4	Craniopharyngioma (Craniopharyngiomas) 01/2023 - 02/2010
4	Neoplasms (Cancer) 01/2022 - 04/2007
4	Hyperinsulinism (Hyperinsulinemia) 01/2019 - 08/2009
3	Glucose Intolerance 12/2017 - 05/2015
3	Vitamin D Deficiency 03/2015 - 01/2011
3	Pediatric Obesity 02/2010 - 08/2009
3	Fetofetal Transfusion (Twin Transfusion Syndrome) 01/2008 - 04/2005
3	Birth Weight (Birth Weights) 01/2008 - 04/2005
2	Hypothalamic Neoplasms 01/2023 - 01/2011
2	Body Weight Changes 01/2021 - 01/2018
2	Nausea 01/2021 - 01/2018
2	Dyslipidemias (Dyslipidemia) 01/2017 - 01/2008
2	Hypertension (High Blood Pressure) 01/2017 - 01/2008
2	Fatty Liver 08/2011 - 11/2008
2	AIDS-Related Complex (ARC) 03/2011 - 01/2011
1	Wounds and Injuries (Trauma) 01/2023
1	Vomiting 01/2021
1	Anorexia 01/2018
1	Prediabetic State (Prediabetes) 12/2017
1	Hyperglycemia 01/2017

Drug/Important Bio-Agent (IBA)

25	Insulin (Novolin)FDA Link 03/2024 - 03/2005
18	Glucose (Dextrose)FDA LinkGeneric 12/2023 - 05/2007
14	LeptinIBA 03/2024 - 01/2006
10	Hormones (Hormone)IBA 12/2023 - 04/2005
9	Triglycerides (Triacylglycerol)IBA 01/2019 - 09/2005
8	LipidsIBA 05/2015 - 09/2005
7	Peptides (Polypeptides)IBA 12/2023 - 01/2010
7	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2023 - 05/2007
7	AdiponectinIBA 08/2016 - 01/2008
5	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 04/2024 - 08/2009
5	MelanocortinsIBA 04/2024 - 02/2010
4	Peptide YYIBA 12/2023 - 12/2005
4	Oxytocin (Pitocin)FDA LinkGeneric 09/2022 - 02/2016
4	Glucagon-Like Peptide-1 ReceptorIBA 01/2022 - 01/2018
4	Exenatide (Byetta)FDA Link 01/2022 - 01/2012
4	C-Reactive ProteinIBA 08/2016 - 09/2005
4	HDL CholesterolIBA 05/2015 - 09/2005
4	ResistinIBA 04/2012 - 01/2008
4	AdipokinesIBA 09/2011 - 01/2008
4	GhrelinIBA 01/2011 - 04/2005
3	High Fructose Corn SyrupIBA 01/2019 - 04/2012
3	Transaminases (Aminotransferases)IBA 01/2017 - 11/2008
3	N(epsilon)-(carboxymethyl)hydroxylysineIBA 01/2017 - 03/2011
3	Vitamin D FDA LinkGeneric 06/2016 - 04/2012
3	Insulin-Like Growth Factor I (IGF-1)IBA 02/2016 - 04/2005
2	FructoseIBA 01/2019 - 08/2016
2	CarbohydratesIBA 01/2018 - 02/2008
2	Blood Glucose (Blood Sugar)IBA 01/2018 - 09/2008
2	EnzymesIBA 01/2017 - 01/2010
2	alpha-2-HS-GlycoproteinIBA 08/2016 - 11/2008
2	hydroxide ionIBA 06/2016 - 01/2011
2	fibroblast growth factor 21IBA 02/2016 - 06/2012
2	salicylhydroxamic acid (SHAM)IBA 02/2016 - 01/2011
2	GlucocorticoidsIBA 04/2013 - 02/2012
2	Sodium Glutamate (Accent)IBA 03/2011 - 01/2011
2	Hemoglobins (Hemoglobin)IBA 01/2011 - 03/2005
2	Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA 02/2010 - 01/2009
2	LDL CholesterolIBA 01/2009 - 09/2008
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2007 - 09/2005
1	setmelanotideIBA 04/2024
1	Liraglutide FDA Link 12/2023
1	neuropeptide Y2 receptorIBA 12/2023
1	NeuropeptidesIBA 12/2023
1	Anti-Obesity Agents (Antiobesity Drugs)IBA 01/2021
1	Endocrine DisruptorsIBA 01/2021
1	6,6'- (ethylenebis(oxyethyleneimino))bis(17- cyclopropylmethyl)- 4,5- epoxymorphinan- 3,14- diolIBA 10/2020
1	TEMPOIBA 10/2020
1	Appetite Depressants (Anorectics)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2018
1	Naltrexone (ReVia)FDA LinkGeneric 01/2018
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 12/2017
1	Angiopoietin-Like Protein 8IBA 09/2017
1	peptide YY (3-36)IBA 01/2017
1	Indicators and Reagents (Reagents)IBA 01/2017
1	CKD732IBA 01/2017
1	Methionine (L-Methionine)FDA Link 01/2017
1	AminopeptidasesIBA 01/2017
1	Melanocyte-Stimulating Hormones (MSH)IBA 10/2016
1	Interleukin-6 (Interleukin 6)IBA 08/2016

Therapy/Procedure

5	Therapeutics 12/2021 - 10/2005
2	Bariatric Surgery 01/2017 - 12/2007
2	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2009 - 12/2007
2	Laser Coagulation 01/2006 - 04/2005
1	Drug Therapy (Chemotherapy) 04/2024
1	Glycemic Control 12/2023
1	Subcutaneous Injections 09/2022
1	Fecal Microbiota Transplantation 11/2017