Assessment of disturbed glucose metabolism and surrogate measures of insulin sensitivity in obese children and adolescents.

Abstract

BACKGROUND:

With the rising prevalence of obesity and type 2 diabetes (T2D) in obese children, it is becoming imperative to detect disturbed glucose metabolism as early as possible in order to prevent T2D development.

SUBJECTS/METHODS:

Cross-sectional study of 92 obese children (median age 11.7 years, 51% female) and 7 lean children (median age 11.4 years, 57% female) who underwent an oral glucose tolerance test (OGTT) in a tertiary pediatric care center. Glucose tolerance was assessed and different indices for β-cell function, insulin sensitivity and insulin secretion were calculated.

RESULTS:

Nineteen obese children were identified with prediabetes (PD, 12 impaired glucose tolerance, 4 increased fasting glucose and 3 combined). Compared with the 73 obese children with normal glucose tolerance (nGT), subjects with PD had higher insulin resistance, but lower insulin sensitivity and β-cell function, although their glycated hemoglobin (HbA1c) levels were comparable. The Whole Body Insulin Sensitivity Index (WBISI) and β-cell function by Insulin Secretion-Sensitivity Index-2 (ISSI-2) strongly correlated with the OGTT glucose area under the curve 0-120 min (r = 0.392, p < 0.0002; r = 0.547, p < 0.0001, respectively). When testing the relation between early insulin response during OGTT by insulinogenic index and insulin sensitivity assessed by WBISI, a hyperbolic relationship between insulin secretion and insulin sensitivity was found. The calculated disposition index was lower in subjects with PD vs. nGT (median 459 vs. 792, p = 0.004). We identified the OGTT 30-min/120-min insulin ratio as a simple marker, which is significantly lower in obese children with vs. without PD (median 0.87 vs. 1.29, p = 0.021) and which has a better sensitivity and specificity for detecting PD than HbA1c among obese children.

CONCLUSIONS:

Children with identified PD had changes of several markers for β-cell function, insulin sensitivity and resistance before changes in HbA1c occurred. The lower disposition index indicates that these children have already inadequate β-cell compensation for the degree of insulin resistance.

• Authors: Christian L Roth, Clinton Elfers, Christiane S Hampe
• Journal: Nutrition & diabetes (Nutr Diabetes) Vol. 7 Issue 12 Pg. 301 (Dec 14 2017) ISSN: 2044-4052 [Electronic] England
• PMID: 29242622 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Glucose

Topics

• Adolescent
• Blood Glucose (metabolism)
• Carbohydrate Metabolism (physiology)
• Child
• Cross-Sectional Studies
• Female
• Glucose (metabolism)
• Glucose Tolerance Test
• Humans
• Insulin Resistance (physiology)
• Insulin-Secreting Cells (metabolism)
• Male
• Pediatric Obesity (metabolism)