Philip Newsholme Selected Research

Insulin Resistance

11/2023	The impact of leucine supplementation on body composition and glucose tolerance following energy restriction: an 8-week RCT in adults at risk of the metabolic syndrome.
12/2022	Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer's Disease.
1/2022	Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels.
11/2020	Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?
10/2020	Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome.
1/2018	Attenuation of obesity and insulin resistance by fish oil supplementation is associated with improved skeletal muscle mitochondrial function in mice fed a high-fat diet.
5/2017	Postprandial changes in glucose oxidation and insulin sensitivity in metabolic syndrome: Influence of fibroblast growth factor 21 and vitamin D status.
1/2017	Winter to summer change in vitamin D status reduces systemic inflammation and bioenergetic activity of human peripheral blood mononuclear cells.
1/2017	The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins.
12/2016	Molecular mechanisms of ROS production and oxidative stress in diabetes.

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Philip Newsholme Research Topics

Disease

25	Insulin Resistance 11/2023 - 01/2007
13	Inflammation (Inflammations) 01/2019 - 01/2012
12	Type 2 Diabetes Mellitus (MODY) 12/2022 - 06/2008
9	Obesity 01/2018 - 02/2004
7	Necrosis 03/2015 - 11/2005
5	Alzheimer Disease (Alzheimer's Disease) 12/2022 - 09/2018
5	Cystinosis 12/2018 - 10/2013
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2023 - 06/2014
4	Cognitive Dysfunction 12/2022 - 01/2015
4	Neoplasms (Cancer) 01/2019 - 02/2016
4	Mitochondrial Diseases (Mitochondrial Disease) 11/2018 - 01/2012
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 11/2009
3	Dementia (Dementias) 01/2022 - 01/2015
3	Body Weight (Weight, Body) 10/2020 - 07/2013
2	Atrophy 12/2019 - 01/2017
2	Hypertrophy 01/2019 - 01/2016
2	Critical Illness (Critically Ill) 10/2018 - 02/2006
1	Chronic Disease (Chronic Diseases) 12/2022
1	Pathologic Processes 01/2020
1	Musculoskeletal Pain 12/2019
1	Sarcopenia 12/2019
1	Adenocarcinoma 04/2019
1	Hepatocellular Carcinoma (Hepatoma) 04/2019
1	Breast Neoplasms (Breast Cancer) 04/2019
1	Disease Progression 01/2019
1	Hyperglycemia 01/2019
1	Ovarian Neoplasms (Ovarian Cancer) 01/2019
1	Muscular Atrophy (Muscle Atrophy) 01/2019
1	Wounds and Injuries (Trauma) 10/2018
1	Sepsis (Septicemia) 10/2018
1	Infections 01/2018
1	Obstructive Lung Diseases (Obstructive Lung Disease) 01/2018
1	Heart Diseases (Heart Disease) 01/2017
1	Muscular Diseases (Myopathy) 01/2017
1	Weight Gain 01/2017
1	Dysbiosis 01/2017

Drug/Important Bio-Agent (IBA)

15	Insulin (Novolin)FDA Link 12/2022 - 02/2004
12	Glucose (Dextrose)FDA LinkGeneric 11/2023 - 10/2007
11	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2007
8	LipidsIBA 10/2020 - 05/2014
5	Fatty Acids (Saturated Fatty Acids)IBA 11/2016 - 02/2006
5	CytokinesIBA 03/2015 - 11/2005
4	Glutamine (L-Glutamine)FDA Link 01/2019 - 01/2016
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 11/2020 - 01/2015
3	Islet Amyloid PolypeptideIBA 01/2020 - 10/2010
3	Vitamin D FDA LinkGeneric 12/2019 - 01/2017
3	Amyloid (Amyloid Fibrils)IBA 09/2018 - 01/2015
3	Alanine (L-Alanine)FDA Link 01/2016 - 11/2005
3	Cystine (L-Cystine)IBA 01/2016 - 10/2013
3	InterleukinsIBA 03/2015 - 10/2010
3	Arginine (L-Arginine)FDA Link 10/2011 - 11/2005
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2015
2	Amyloid beta-PeptidesIBA 01/2020 - 09/2018
2	AntioxidantsIBA 01/2020 - 01/2019
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2019 - 01/2017
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 11/2018 - 11/2005
2	Amino Acids FDA Link 10/2018 - 11/2009
2	Fish OilsIBA 01/2018 - 01/2016
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 03/2015
2	Blood Glucose (Blood Sugar)IBA 01/2017 - 07/2013
2	CholesterolIBA 01/2017 - 01/2015
2	Interleukin-10 (Interleukin 10)IBA 01/2017 - 03/2015
2	Sirtuin 1IBA 12/2016 - 04/2016
2	pigment epithelium-derived factorIBA 05/2016 - 01/2016
2	Streptozocin (Streptozotocin)FDA Link 01/2016 - 01/2012
2	NADPH Oxidases (NAD(P)H oxidase)IBA 06/2015 - 11/2005
2	InflammasomesIBA 07/2014 - 10/2010
2	AdiponectinIBA 05/2014 - 11/2012
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2014 - 11/2009
2	Adenosine Triphosphate (ATP)IBA 10/2013 - 01/2012
2	InterferonsIBA 10/2011 - 12/2010
1	Leucine (L-Leucine)FDA Link 11/2023
1	Volatile Fatty AcidsIBA 10/2020
1	Butyrates (Butyrate)IBA 10/2020
1	Amyloidogenic ProteinsIBA 01/2020
1	CatalaseIBA 01/2020
1	NitrogenIBA 01/2020
1	Oxygen (Dioxygen)IBA 01/2020
1	Peroxidase (Myeloperoxidase)IBA 01/2020
1	Liver ExtractsIBA 04/2019
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2019
1	Histones (Histone)IBA 01/2019
1	Nonesterified Fatty Acids (NEFA)IBA 01/2019
1	Secreted Frizzled-Related ProteinsIBA 01/2019
1	Adenosine Triphosphatases (ATPase)IBA 11/2018
1	Citric Acid (Citrate)FDA LinkGeneric 01/2018
1	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2018
1	Oxaloacetic Acid (Oxalacetic Acid)IBA 01/2018
1	Metformin (Glucophage)FDA LinkGeneric 01/2018
1	malic acid (malate)IBA 01/2018
1	Chemotactic FactorsIBA 01/2018
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2018
1	Hormones (Hormone)IBA 06/2017
1	fibroblast growth factor 21IBA 05/2017
1	Interleukin-8 (Interleukin 8)IBA 01/2017
1	hydroxide ionIBA 01/2017
1	Bile Acids and Salts (Bile Acids)IBA 01/2017
1	tau Proteins (tau Protein)IBA 01/2017

Therapy/Procedure

6	Therapeutics 11/2018 - 02/2006