Malcolm R Macleod Selected Research

Neuroprotective Agents

8/2018	NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons.
1/2015	Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis.
4/2013	The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine.
3/2011	Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing.
5/2010	A systematic review and meta-analysis of erythropoietin in experimental stroke.
6/2009	Injury-induced mineralocorticoid receptor expression involves differential promoter usage: a novel role for the rat MRbeta variant.
1/2008	A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke.
1/2005	Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke.
5/2004	Pooling of animal experimental data reveals influence of study design and publication bias.

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Malcolm R Macleod Research Topics

Disease

27	Stroke (Strokes) 01/2024 - 02/2003
20	Ischemic Stroke 01/2024 - 01/2005
13	Infarction (Infarctions) 01/2021 - 06/2005
7	Hypothermia 10/2017 - 12/2007
5	Spinal Cord Injuries (Spinal Cord Injury) 01/2016 - 01/2013
4	Ischemia 01/2019 - 05/2004
4	Brain Ischemia (Cerebral Ischemia) 10/2014 - 10/2008
3	Brain Injuries (Brain Injury) 01/2021 - 04/2003
3	Heart Arrest (Cardiac Arrest) 01/2013 - 04/2003
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021 - 10/2020
2	Infections 09/2018 - 02/2014
2	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2017 - 07/2015
2	Hypertension (High Blood Pressure) 08/2013 - 05/2010
1	Psychotic Disorders (Schizoaffective Disorder) 01/2023
1	Anemia 01/2021
1	Cerebral Hemorrhage 01/2021
1	Type 2 Diabetes Mellitus (MODY) 01/2020
1	Obesity 01/2020
1	Cognitive Dysfunction 01/2020
1	Atrial Fibrillation 10/2019
1	Carotid Stenosis (Carotid Artery Stenosis) 10/2019
1	Proteostasis Deficiencies 08/2019
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 08/2019
1	Cerebral Infarction 01/2019
1	Fever (Fevers) 09/2018
1	Neoplasms (Cancer) 02/2018
1	Epilepsy (Aura) 11/2017
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2017
1	Rheumatoid Arthritis 10/2016
1	Myocardial Infarction 04/2016
1	Breast Neoplasms (Breast Cancer) 01/2016
1	Fatigue 07/2015
1	Chronic Disease (Chronic Diseases) 07/2015
1	Chronic Progressive Multiple Sclerosis 01/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015
1	Cancer Pain 06/2014
1	Sepsis (Septicemia) 02/2014
1	Pneumonia (Pneumonitis) 02/2014
1	Contusions 01/2014

Drug/Important Bio-Agent (IBA)

9	Neuroprotective AgentsIBA 08/2018 - 05/2004
4	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2019 - 12/2010
3	Oxygen (Dioxygen)IBA 01/2021 - 07/2014
3	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2021 - 07/2009
3	Proteins (Proteins, Gene)FDA Link 10/2016 - 02/2003
2	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2024 - 09/2018
2	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2024 - 09/2018
2	Metoclopramide (Reglan)FDA LinkGeneric 01/2024 - 09/2018
2	Glucose (Dextrose)FDA LinkGeneric 08/2018 - 07/2014
2	disufenton sodium (NXY 059)IBA 08/2018 - 10/2008
2	Interleukin-1 (Interleukin 1)IBA 10/2016 - 07/2009
2	Antidepressive Agents (Antidepressants)IBA 07/2015 - 10/2014
2	Meperidine (Pethidine)FDA LinkGeneric 07/2014 - 04/2013
2	MelatoninIBA 03/2011 - 01/2005
2	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2009 - 04/2003
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2024
1	AntipyreticsIBA 01/2024
1	AntiemeticsIBA 01/2024
1	Trace amine-associated receptor 1IBA 01/2023
1	Antipsychotic Agents (Antipsychotics)IBA 01/2023
1	FatsIBA 01/2020
1	SugarsIBA 01/2020
1	CholesterolIBA 10/2019
1	DNA-Binding Proteins (DNA Binding Protein)IBA 08/2019
1	Superoxide Dismutase-1IBA 08/2019
1	Indicators and Reagents (Reagents)IBA 08/2018
1	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 08/2018
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 08/2018
1	A-factor (Streptomyces)IBA 02/2018
1	Calcitonin Gene-Related PeptideIBA 01/2017
1	Vasodilator Agents (Vasodilators)IBA 01/2017
1	Trastuzumab (Herceptin)FDA Link 01/2016
1	Fluoxetine (Prozac)FDA LinkGeneric 07/2015
1	sulbutiamine (Arcalion)IBA 07/2015
1	tirilazadIBA 07/2015
1	Cytidine Diphosphate Choline (Citicoline)IBA 07/2015
1	OSU 6162IBA 07/2015
1	Endothelin Receptor AntagonistsIBA 07/2015
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 10/2014
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 07/2014
1	Buspirone (Buspar)FDA LinkGeneric 07/2014
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 07/2014
1	Saline SolutionIBA 07/2014
1	Monomeric GTP-Binding ProteinsIBA 01/2014
1	Y 27632IBA 01/2014
1	fasudil (AT 877)IBA 01/2014
1	Ibuprofen (Motrin)FDA LinkGeneric 01/2014
1	Anesthetics (Anesthetic Agents)IBA 08/2013

Therapy/Procedure

15	Therapeutics 01/2019 - 03/2006
10	Induced Hypothermia 10/2020 - 12/2007
2	Secondary Prevention 10/2019 - 05/2006
1	Erythrocyte Transfusion 01/2021
1	Carotid Endarterectomy 10/2019
1	Thrombectomy 10/2019
1	Cell Transplantation 01/2016
1	Transplantation 01/2016
1	Aftercare (After-Treatment) 07/2015
1	Continuous Positive Airway Pressure 07/2015
1	Intravenous Infusions 07/2014
1	Endovascular Procedures 07/2014
1	Stem Cell Transplantation 12/2013