Abstract | BACKGROUND/OBJECTIVE: METHODS: We present a systematic review of reports describing the use of piracetam and its derivatives in animal models of focal ischaemia, where the outcome was measured as an infarct size or neurological score (Der Simonian and Laird random effects meta-analysis). RESULTS: Only 2 studies, published 10 years after the first clinical trial of piracetam had been initiated, described its efficacy in animal models of stroke. A further 4 studies described the efficacy of related compounds. Piracetam and its derivatives improved the outcome by 30.2% (95% CI = 16.1-44.4). The median study quality was 4/10 (inter-quartile range = 4-6). CONCLUSION:
Piracetam and its derivatives demonstrate neuroprotective efficacy in experimental stroke, but our findings raise concerns about the amount of available data, the quality of the studies and publication bias.
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Authors | Philippa C R Wheble, Emily S Sena, Malcolm R Macleod |
Journal | Cerebrovascular diseases (Basel, Switzerland)
(Cerebrovasc Dis)
Vol. 25
Issue 1-2
Pg. 5-11
( 2008)
ISSN: 1421-9786 [Electronic] Switzerland |
PMID | 18033952
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
|
Copyright | (c) 2007 S. Karger AG, Basel. |
Chemical References |
- Neuroprotective Agents
- Piracetam
|
Topics |
- Animals
- Disease Models, Animal
- Neuroprotective Agents
(therapeutic use)
- Piracetam
(analogs & derivatives, therapeutic use)
- Stroke
(drug therapy)
|