Juha Klefström Selected Research

Breast Neoplasms (Breast Cancer)

4/2024	Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment.
10/2023	Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis.
9/2023	Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells.
1/2022	Sortilin-related receptor is a druggable therapeutic target in breast cancer.
11/2021	Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer.
11/2021	Hepsin regulates TGFβ signaling via fibronectin proteolysis.
1/2020	UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis.
1/2019	Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology.
1/2016	MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures.
1/2016	Data integration to prioritize drugs using genomics and curated data.

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Juha Klefström Research Topics

Disease

26	Neoplasms (Cancer) 04/2024 - 07/2008
12	Breast Neoplasms (Breast Cancer) 04/2024 - 07/2008
2	Squamous Cell Carcinoma of Head and Neck 01/2024 - 03/2021
2	Triple Negative Breast Neoplasms 11/2022 - 01/2022
2	Carcinogenesis 01/2021 - 01/2018
2	Neoplasm Metastasis (Metastasis) 01/2018 - 05/2015
1	Acquired Immunodeficiency Syndrome (AIDS) 09/2023
1	Circulating Neoplastic Cells 09/2023
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2023
1	Hematologic Neoplasms (Hematological Malignancy) 01/2019
1	Ovarian Neoplasms (Ovarian Cancer) 01/2018
1	Neuroblastoma 11/2013
1	B-Cell Lymphoma (Lymphoma, B Cell) 05/2013
1	Peutz-Jeghers Syndrome (Polyposis, Hamartomatous Intestinal) 01/2013
1	Prostatic Neoplasms (Prostate Cancer) 11/2009
1	Infections 11/2009

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 10/2023 - 11/2009
6	hepsinIBA 10/2023 - 01/2018
5	Peptide Hydrolases (Proteases)FDA Link 11/2021 - 04/2017
3	CytokinesIBA 04/2024 - 09/2010
3	Serine Proteases (Serine Protease)IBA 10/2023 - 04/2017
3	Phenobarbital (Luminal)FDA Link 11/2021 - 05/2015
3	Phosphotransferases (Kinase)IBA 01/2019 - 02/2012
2	Transcription Factors (Transcription Factor)IBA 01/2023 - 01/2018
2	Estrogen ReceptorsIBA 11/2021 - 01/2016
2	CollagenIBA 03/2021 - 01/2021
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 04/2024
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2024
1	ErbB Receptors (EGF Receptor)IBA 10/2023
1	Neutralizing AntibodiesIBA 10/2023
1	GelsIBA 09/2023
1	FibrinIBA 09/2023
1	NucleotidesIBA 01/2023
1	Glutamine (L-Glutamine)FDA Link 01/2023
1	Monoclonal AntibodiesIBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	Trastuzumab (Herceptin)FDA Link 01/2022
1	sortilinIBA 01/2022
1	tyrosine receptor (receptor, tyrosine)IBA 01/2022
1	Protein Kinases (Protein Kinase)IBA 01/2022
1	InterferonsIBA 01/2022
1	p38 Mitogen-Activated Protein KinasesIBA 11/2021
1	Transforming Growth Factor beta (TGF-beta)IBA 11/2021
1	Fibronectins (Fibronectin)IBA 11/2021
1	Anoctamin-1IBA 03/2021
1	ras ProteinsIBA 01/2021
1	UbiquitinIBA 01/2020
1	Ligases (Synthetase)IBA 01/2020
1	venetoclaxIBA 01/2019
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2019
1	Metformin (Glucophage)FDA LinkGeneric 01/2019
1	navitoclaxIBA 01/2019
1	matriptaseIBA 01/2019
1	HGF activatorIBA 01/2019
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2018
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/2015
1	Serine (L-Serine)FDA Link 11/2013
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 11/2013
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 11/2013
1	Tumor Suppressor Protein p53IBA 05/2013
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2013
1	GATA4 Transcription FactorIBA 09/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2010
1	LigandsIBA 09/2010
1	Hormones (Hormone)IBA 11/2009
1	Small Interfering RNA (siRNA)IBA 07/2008
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 07/2008
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 07/2008

Therapy/Procedure

6	Therapeutics 01/2022 - 11/2009
2	Immunotherapy 11/2022 - 01/2022
1	Drug Therapy (Chemotherapy) 04/2024