D M Holtzman Selected Research

Therapeutics

10/2002

Apolipoprotein E, amyloid, and Alzheimer disease.

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D M Holtzman Research Topics

Disease

19	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 01/2000
7	Dementia (Dementias) 11/2015 - 05/2001
5	Brain Injuries (Brain Injury) 01/2003 - 07/2000
4	Ischemia 01/2003 - 02/2000
4	Amyloid Plaque 10/2001 - 03/2000
3	Cognitive Dysfunction 03/2012 - 01/2003
3	Hypoxia (Hypoxemia) 03/2001 - 02/2000
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 10/2001 - 06/2000
1	Tauopathies 01/2017
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2017
1	Gliosis 07/2010
1	Mitochondrial Diseases (Mitochondrial Disease) 10/2003
1	Stroke (Strokes) 01/2003
1	Brain Ischemia (Cerebral Ischemia) 01/2003
1	Necrosis 09/2001
1	Cerebral Palsy (Spastic Diplegia) 03/2001
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 02/2001
1	Memory Disorders (Memory Loss) 11/2000
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2000
1	Wounds and Injuries (Trauma) 07/2000

Drug/Important Bio-Agent (IBA)

11	Apolipoproteins E (ApoE)IBA 01/2003 - 03/2000
10	ApolipoproteinsIBA 01/2003 - 01/2000
6	Amyloid (Amyloid Fibrils)IBA 11/2015 - 03/2000
5	Caspase 3 (Caspase-3)IBA 10/2003 - 02/2000
5	Protein Isoforms (Isoforms)IBA 01/2003 - 03/2000
4	Proteins (Proteins, Gene)FDA Link 11/2015 - 01/2000
4	Biomarkers (Surrogate Marker)IBA 03/2012 - 12/2009
4	Amyloid beta-PeptidesIBA 07/2009 - 01/2000
3	AntibodiesIBA 01/2017 - 07/2001
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 11/2000 - 02/2000
3	Apolipoprotein E3IBA 08/2000 - 03/2000
2	Peptides (Polypeptides)IBA 07/2009 - 07/2001
2	CaspasesIBA 01/2003 - 03/2001
2	Apolipoprotein E4IBA 01/2003 - 03/2000
2	Lipoproteins (Lipoprotein)IBA 08/2000 - 01/2000
1	tilavonemabIBA 01/2017
1	cresyl violetIBA 07/2010
1	Coloring Agents (Dyes)IBA 07/2010
1	N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA 02/2006
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2006
1	Cytochromes c (Cytochrome c)IBA 10/2003
1	PlasmalogensIBA 05/2001
1	phosphatidal ethanolaminesIBA 05/2001
1	ClusterinIBA 03/2001
1	Nerve Growth Factor (NGF)IBA 02/2001
1	Nerve Growth Factors (Neurotrophins)IBA 11/2000
1	Cytoskeletal ProteinsIBA 08/2000
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 08/2000
1	N-Methylaspartate (NMDA)IBA 07/2000
1	Excitatory Amino Acid AgonistsIBA 07/2000
1	StaurosporineIBA 07/2000
1	Glutamic Acid (Glutamate)FDA Link 07/2000
1	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2000
1	LigandsIBA 01/2000

Therapy/Procedure

2	Ligation 11/2000 - 02/2000
1	Therapeutics 10/2002