Apolipoprotein E, amyloid, and Alzheimer disease.

Abstract

Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (apoE). The risk that specific isoforms of apoE pose with regard to Alzheimer Disease clearly varies, and so the roles that apoE plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies.

• Authors: K R Bales, J C Dodart, R B DeMattos, D M Holtzman, S M Paul
• Journal: Molecular interventions (Mol Interv) Vol. 2 Issue 6 Pg. 363-75, 339 (Oct 2002) ISSN: 1534-0384 [Print] United States
• PMID: 14993413 (Publication Type: Journal Article, Review)

Chemical References

• Amyloid
• Amyloid beta-Peptides
• Apolipoproteins E

Topics

• Alzheimer Disease (genetics, physiopathology)
• Amyloid (metabolism)
• Amyloid beta-Peptides (metabolism)
• Animals
• Apolipoproteins E (genetics, metabolism)
• Central Nervous System (metabolism)
• Genetic Predisposition to Disease
• Humans
• Mice