HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

J David Brook Selected Research

Myotonic Dystrophy (Dystrophia Myotonica)

1/2020CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.
1/2019Global Increase in Circular RNA Levels in Myotonic Dystrophy.
12/2018Quantitative Methods to Monitor RNA Biomarkers in Myotonic Dystrophy.
3/2014High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines.
11/2011Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.
1/2009Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle.
9/2007Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles.
11/2006Flies deficient in Muscleblind protein model features of myotonic dystrophy with altered splice forms of Z-band associated transcripts.
4/2002Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown:


J David Brook Research Topics

Disease

9Myotonic Dystrophy (Dystrophia Myotonica)
01/2020 - 04/2002
5Congenital Heart Defects (Congenital Heart Defect)
01/2017 - 04/2005
3Holt-Oram syndrome
11/2019 - 04/2003
2Tetralogy of Fallot (Fallot Tetralogy)
04/2012 - 01/2009
1Muscle Weakness
01/2019
1Genetic Translocation (Chromosomal Translocation)
01/2014
1Cardiomegaly (Heart Hypertrophy)
06/2009
1Muscular Diseases (Myopathy)
11/2006
1Atrial Heart Septal Defects (Atrial Septal Defect)
04/2005
1DiGeorge Syndrome (Syndrome, DiGeorge)
04/2003
1Cleft Palate with Ankyloglossia
04/2003
1Ulnar-mammary syndrome
04/2003

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
11/2019 - 04/2005
3RNA (Ribonucleic Acid)IBA
01/2020 - 11/2011
2Protein Kinases (Protein Kinase)IBA
01/2020 - 01/2019
2Transcription Factors (Transcription Factor)IBA
11/2019 - 04/2005
2Biomarkers (Surrogate Marker)IBA
01/2019 - 12/2018
2DNA (Deoxyribonucleic Acid)IBA
01/2017 - 04/2002
13' Untranslated Regions (3' UTR)IBA
01/2020
1RNA Splicing FactorsIBA
01/2019
1Circular RNAIBA
01/2019
1TropomyosinIBA
01/2017
1CELF1 ProteinIBA
03/2014
1RNA Splice SitesIBA
01/2014
1Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA
08/2013
1Ventricular MyosinsIBA
06/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2009
1Messenger RNA (mRNA)IBA
09/2007
1Protein Isoforms (Isoforms)IBA
11/2006
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
04/2005
1Adrenocorticotropic Hormone (ACTH)FDA Link
04/2003

Therapy/Procedure

1Ligation
04/2012