Abstract | OBJECTIVE: METHODS: RESULTS: Of 54 patients with aPL, 33 showed significantly high levels of IgA aCL. Among them, IgA aCL coexisted with other aCL isotypes or LAC in 24 patients. The 9 patients with IgA aCL alone frequently had vasculitis associated manifestations, although thrombotic events and recurrent fetal loss were rare. Multivariate linear regression analysis showed that IgA aCL were independently associated with thrombocytopenia, skin ulcers, chilblain lupus, and vasculitis. There was also an association between IgM aCL and skin ulcers or chilblain lupus. CONCLUSION: Clinical manifestations of patients with IgA aCL differ from those of patients with IgG aCL. Determination of all 3 aCL isotypes and LAC is important to assess the risk of specific clinical manifestations in patients with aPL.
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Authors | C Tajima, Y Suzuki, Y Mizushima, Y Ichikawa |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 25
Issue 9
Pg. 1730-6
(Sep 1998)
ISSN: 0315-162X [Print] Canada |
PMID | 9733453
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Antiphospholipid
- Immunoglobulin A
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Topics |
- Adult
- Aged
- Antibodies, Antiphospholipid
(adverse effects, immunology)
- Antibody Affinity
- Autoimmune Diseases
(complications, immunology)
- Blood Vessels
(immunology)
- Collagen Diseases
(immunology)
- Female
- Humans
- Immunoglobulin A
(immunology)
- Male
- Middle Aged
- Retrospective Studies
- Skin Diseases
(immunology)
- Skin Ulcer
(etiology, immunology)
- Vasculitis
(etiology, immunology)
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