Abstract | OBJECTIVES: METHODS: The effects of these drugs on plaque growth after MDV infection were examined in two studies. In Study 1, MDV infected White Leghorn rooster chicks were divided into 4 groups assigned to normal or high cholesterol diet, and treated at three months of age with either pravastatin or saline. In Study 2, cholesterol fed rooster chicks infected with MDV were divided into 3 groups for treatment with either pravastatin, quinapril, or saline control. RESULTS: A significant decrease in plaque area was detected after 60 days of treatment with both pravastatin and quinapril in cholesterol fed chicks (P < 0.001). Lymphocyte infiltration into the arterial wall or target organs was not inhibited by treatment with either drug. CONCLUSIONS:
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Authors | A Lucas, E Dai, L Y Liu, P N Nation |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 38
Issue 1
Pg. 237-46
(Apr 1998)
ISSN: 0008-6363 [Print] England |
PMID | 9683927
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Isoquinolines
- Tetrahydroisoquinolines
- Cholesterol
- Pravastatin
- Quinapril
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Animals
- Arteriosclerosis
(complications, drug therapy, immunology, virology)
- Carotid Arteries
(immunology, pathology)
- Chickens
- Cholesterol
(blood)
- Disease Models, Animal
- Herpesvirus 2, Gallid
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Hypercholesterolemia
(complications, drug therapy)
- Isoquinolines
(therapeutic use)
- Lymphocytes
(immunology)
- Marek Disease
(complications, immunology)
- Pravastatin
(therapeutic use)
- Quinapril
- Tetrahydroisoquinolines
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