Sensodyne F is a
potassium chloride (KCl) and
sodium monofluorphosphate (MFP) containing
dentifrice currently marketed in the United Kingdom and Germany was compared to a KCl only
dentifrice and to a placebo
dentifrice for effectiveness in alleviating
dentin hypersensitivity. This 3-cell, randomized, double-blind, parallel clinical study utilized 62 subjects for an 8-week duration of product use. The degree of
hypersensitivity of the affected teeth was assessed by tactile stimulation, cold air stimulation and overall subjective patient response. The results from these three methods of assessment indicated that a KCl containing
dentifrice either alone or in combination with
sodium MFP were significantly more effective than the placebo
dentifrice in reducing
dentin hypersensitivity. The therapeutic response to the KCl
dentifrices as measured by air sensitivity and tactile sensitivity was statistically significant when compared to the placebo
dentifrice within 4 weeks of use. Significant improvement was seen for all parameters at the conclusion of the 8-week clinical study period. Plaque reduction was significantly reduced at 8 weeks. The results indicate that KCl is an efficacious molecule in reducing
dentin hypersensitivity when used either alone or in combination with
sodium MFP as measured by improved overall patient comfort.