Following intraperitoneal(IP) administration of
cis-diamminedichloroplatinum(CDDP), a dynamic study was conducted on rabbits in
Angiotensin II(ATII) induced
hypertension to investigate hemodynamic changes in VX2 ovarian
tumors. VX2
tumors for
transplantation were prepared in Japanese white female rabbits. 15mg/kg of CDDP in 30ml/kg
0.9% NaCl solution was IP administration to the rabbits. The tissue
platinum(Pt) concentration was measured and
tumor vascular model prepared. The rabbits also received IP combined with 1.2g/kg
intravenous administration of
sodium thiosulfate(STS), and a hemodynamic study was run on rabbits with ATII induced
hypertension two weeks after administration. IP administration resulted in tissue Pt levels as high as 18.50 +/- 8.05 micrograms/g in the VX2 ovarian
tumors, with a tiny non-enhanced area appearing in the rim enhancement, consistent with necrotic changes. The
tumor time-density curve following IP was characterized by a markedly delayed washout, with many hypovascular portions noted in the vascular model and a clear decrease in
tumor vessels measuring 30 microns or less. in contrast, the peak value increased in the time-density curve and there was washout in the excretory phase following ATII induced
hypertension. In view of the results, we suggest that a microcirculatory disorder resulting from IP administration could be improved under ATII induced
hypertension.