Injectable collagen for type 3 female stress incontinence: the first 50 Australian patients.

Abstract

OBJECTIVE:

To assess the safety, efficacy and durability of injectable glutaraldehyde cross-linked (GAX) collagen in the treatment of type 3 female stress incontinence.

DESIGN AND SETTING:

A prospective study of incontinent women attending a private practice for clinical and urodynamic assessment.

PATIENTS:

Fifty women who had had an average of 1.8 previous operations for stress urinary incontinence took part in the study. Each had been diagnosed as having type 3 genuine stress incontinence (poor or nonfunctioning urethral sphincter mechanism in the presence of a bladder neck which is well supported, usually by scar tissue from previous surgery). Subject to a negative skin test for allergy, each patient underwent the implantation of GAX collagen (Contigen), a biocompatible product causing no foreign body reaction.

INTERVENTIONS:

The implant was performed by a short day-only procedure involving cystoscopically controlled periurethral (71%) or transurethral (29%) injection of Contigen. The aim was to achieve closure of the urethra at the bladder neck and increase resistance to urine loss. Top-up injections were used as required. The follow-up period ranged from one to 21 months (mean, 11 months).

RESULTS:

Of these first 50 female patients, 41 (82%) were successfully treated. Twenty-one (42%) were no longer incontinent; 20 (40%) desired no further treatment because their condition was improved; seven (14%) did not respond to treatment and two patients were awaiting top-up injections. The average number of injections given was 1.9 and the average volume injected was 14.4 mL. There were no allergic reactions or infections. Side effects were temporary and of a minor nature.

CONCLUSIONS:

Injectable GAX collagen appears to be a safe and effective treatment for type 3 stress urinary incontinence. Its durability awaits further follow-up.

• Authors: P Stricker, B Haylen
• Journal: The Medical journal of Australia (Med J Aust) Vol. 158 Issue 2 Pg. 89-91 (Jan 18 1993) ISSN: 0025-729X [Print] Australia
• PMID: 8419782 (Publication Type: Journal Article)

Chemical References

• GAX-collagen
• Collagen

Topics

• Collagen (analogs & derivatives)
• Female
• Follow-Up Studies
• Humans
• Injections
• Prospective Studies
• Prostheses and Implants
• Treatment Outcome
• Urinary Incontinence, Stress (surgery)