We evaluated the clinical and pathophysiological efficacy of hyposensitization with
house dust extracts to perennial nasal
allergy. Fifty-one patients with allergic perennial
rhinitis completed 5 months to 15 years with a mean of 2.4 years course of hyposensitization treatment with
house dust extracts, and analyzed clinical symptoms, nasal provocation testing, nasal
hypersensitivity to
histamine, mast cells and eosinophils in nasal scraping, specific
IgG and
IgG4 antibody in serum, and blood eosinophils and basophils in relation to therapeutic duration. The improvement in nasal symptoms was found in 74.1% in adults and 66.7% in child and the continuation of hyposensitization with
house dust extracts for a half to one year showed significant improvement of clinical symptoms. In objective examination, nasal provocation testing, nasal
hypersensitivity to
histamine, the number of mast cells and eosinophils in nasal scraping, and blood basophils showed significant improvement at 6 to 12 months the same as clinical symptoms. These findings suggest that the continuation of hyposensitization with
house dust extracts is recommendable as a basic treatment against perennial nasal
allergy.