Abstract |
The carcinogenicity of the nitrosourea amino acid, N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine ( MNCO), and its acute cytotoxicity were studied in Wistar rats. MNCO treatment induced a high incidence of neoplasms in breast, kidney, and skin and a lower incidence of tumors in the exocrine pancreas and ear duct. The duration of these studies was limited by toxicity and carcinogenicity to six months in a high dose group which received 1 mmole MNCO/kg IP weekly for 6 months and to 1 year in a group which received 0.33 mmole/kg. In the latter group the incidence of neoplasms was breast, 40%; skin, 52%; kidney, 81%; pancreas, 19%; and ear duct, 4%. All pancreases in this group also contained foci of fibrosis and cyst formation, and atypical acinar cell nodules. Acute cytotoxic effects were noted in pancreas, kidney and skin after a single IP injection of 3 mmoles/kg although this dose caused no deaths acutely.
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Authors | D S Longnecker, T J Curphey, H S Lilja, J I French, D S Daniel |
Journal | Journal of environmental pathology and toxicology
(J Environ Pathol Toxicol)
Vol. 4
Issue 1
Pg. 117-29
(Aug 1980)
ISSN: 0146-4779 [Print] United States |
PMID | 7441106
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Carcinogens
- Nitrosourea Compounds
- N(delta)-(N-methyl-N-nitrosocarbamoyl)-L-ornithine
- Ornithine
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Topics |
- Animals
- Body Weight
(drug effects)
- Carcinogens
(metabolism)
- Female
- Male
- Neoplasms, Experimental
(chemically induced, pathology)
- Nitrosourea Compounds
(metabolism, toxicity)
- Ornithine
(analogs & derivatives, metabolism, toxicity)
- Pancreatic Neoplasms
(chemically induced)
- Rats
- Tissue Distribution
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