Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication.

Abstract

The sodium and ammonium salts of N-methyl-D-glucamine dithiocarbamate were prepared and their usefulness as antidotes for cadmium intoxication investigated. This chelating agent was found to be effective in both acute and repeated exposure cadmium poisoning. A single intraperitoneal injection of sodium N-methyl-D-glucamine dithiocarbamate (NaNMG-DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal (greater than 95%) dose of cadmium chloride (10 mg CdCl2/kg body weight) and results in a subsequent dose-dependent decrease in the liver and kidney burdens of cadmium ion. In repeated exposure cadmium intoxication, repeated administration of NaNMG-DTC can result in substantial reductions in both the kidney (71%) and the liver (40%) levels of cadmium. The LD50 of the compound was not determined, but single injections of 26.6 mmol/kg body weight (injectate volume 1.0 ml) are well tolerated in mice.

• Authors: L A Shinobu, S G Jones, M M Jones
• Journal: Acta pharmacologica et toxicologica (Acta Pharmacol Toxicol (Copenh)) Vol. 54 Issue 3 Pg. 189-94 (Mar 1984) ISSN: 0001-6683 [Print] Denmark
• PMID: 6720318 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antidotes
• Carbamates
• Chelating Agents
• Spin Labels
• Thiocarbamates
• Cadmium
• Sorbitol
• N-methyl-D-glucamine dithiocarbamate

Topics

• Animals
• Antidotes (therapeutic use)
• Cadmium (metabolism)
• Cadmium Poisoning (drug therapy)
• Carbamates (therapeutic use, toxicity)
• Chelating Agents (therapeutic use)
• Lethal Dose 50
• Male
• Mice
• Mice, Inbred ICR
• Sorbitol (analogs & derivatives)
• Spin Labels
• Testis (drug effects)
• Thiocarbamates