The present study was aimed to evaluate the acute and chronic hypotensive effects of
nifedipine (
Bay a 1040,
Adalat) and
niludipine (
Bay a 7168) in hypertensive patients with
chronic renal failure. 1. The decrease of blood pressure lasted for at least 3 h and maximum decrement was achieved in 60 min (26% decrement, p less than 0.05) after
oral administration of
nifedipine (10 mg). On the other hand,
niludipine (20 mg) caused decrease of blood pressure for at least 4 h and attained maximum decrement in 90 min (13% decrement, p less than 0.05) after
oral administration. 2. In chronic studies of both drugs, the maximum decrease of blood pressure (p less than 0.05) was attained after one week and lasted at least 4 weeks. There were no significant changes of pulse rate,
body weight and urine volume in both
nifedipine and
niludipine groups. 3.
Nifedipine caused great diurnal or day-to-day fluctuations of blood pressures after chronic administrations. On the other hand
niludipine did not cause any significant fluctuations. Any serious complications could not be seen during these studies. In conclusion, these results provide clinical evidence that
niludipine could be usefused great diurnal or day-to-day fluctuations of blood pressures after chronic administrations. On the other hand
niludipine did not cause any significant fluctuations. Any serious complications could not be seen during these studies. In conclusion, these results provide clinical evidence that
niludipine could be useful for treatment of
hypertension associated with
chronic renal failure. Results also suggest that the optimal efficacy of
nifedipine and
niludipine in part depends on the specific clinical situation at hand. For example,
nifedipine seems to be the
drug of choice in
hypertensive emergencies when there is a need for rapid lowering of blood pressure.