Objective: To understand ten-year changes in clinical characteristics and
antiviral treatment patterns of
chronic hepatitis B in China. Methods: Patients with chronic HBV
infection:demographic, virologic, hematologic, blood biochemistry, and
antiviral treatment data were extracted from the China Registry of
Hepatitis B (CR-
HepB) database between 2012 and 2022 for descriptive statistics and change trend analysis. Multiple group comparisons were conducted using the Kruskal Wallis H test, while counting data was compared between groups using χ (2) test. Results: A total of 180 012 patients with chronic HBV
infection were included, with a median age of 40 years old, and a male proportion accounting for 60.2%. The
HBeAg positive rate was 43.3%. Over time, the median age of new patients each year increased from 39 to 47 years, while the
HBeAg positive rate decreased from 51.3% to 32.8%. The initial diagnosis of patients was mainly CHB (71.4%), followed by
hepatitis B cirrhosis (11.8%), inactive
HBsAg carrier status (10.6%), and chronic HBV carrier status (6.2%). Among the newly registered patients every year from 2012 to 2022, the proportion of
hepatitis B cirrhosis remained stable, but after 2019, the proportion of CHB increased and the proportion of other diagnoses decreased. The proportion of patients with
cirrhosis increased with age in different age groups, with 3.5%, 19.3%, and 30.4% in the < 40, 40-69, and≥70 age groups, respectively. The proportion of women in patients with
cirrhosis also increased with age, from 16.1% in those < 30 years old to 44.3% in those≥80 years old. From 2012 to 2022, the proportion of patients receiving first-line nucleos(t)ide analog
antiviral treatment increased year by year, from 51.0% in 2012-2013 to 99.8% in 2022. Conclusion: The CR-
HepB registration data reflect the changes in clinical characteristics and
antiviral treatment patterns in patients with chronic HBV
infection in China over the past ten years and can thus provide a reference to promote
hepatitis B diagnosis and treatment practice, as well as scientific research.