Abstract | OBJECTIVE: The aim of this study was to evaluate the efficacy of yttrium-90 transarterial radioembolization (TARE) to convert to resection initially unresectable, single, large (≥5 cm) hepatocellular carcinoma (HCC). BACKGROUND: TARE can downsize cholangiocarcinoma to resection but its role in HCC resectability remains debatable. METHODS: All consecutive patients with a single large HCC treated between 2015 and 2020 in a single tertiary center were reviewed. When indicated, patients were either readily resected (upfront surgery) or underwent TARE. TARE patients were converted to resection (TARE surgery) or not (TARE-only). To further assess the effect of TARE on the long-term and short-term outcomes, a propensity score matching analysis was performed. RESULTS: Among 216 patients, 144 (66.7%) underwent upfront surgery. Among 72 TARE patients, 20 (27.7%) were converted to resection. TARE-surgery patients received a higher mean yttrium-90 dose that the 52 remaining TARE-only patients (211.89±107.98 vs 128.7±36.52 Gy, P <0.001). Postoperative outcomes between upfront-surgery and TARE-surgery patients were similar. In the unmatched population, overall survival at 1, 3, and 5 years was similar between upfront-surgery and TARE-surgery patients (83.0%, 60.0%, 47% vs 94.0%, 86.0%, 55.0%, P =0.43) and compared favorably with TARE-only patients (61.0%, 16.0% and 9.0%, P <0.0001). After propensity score matching, TARE-surgery patients had significantly better overall survival than upfront-surgery patients ( P =0.021), while disease-free survival was similar ( P =0.29). CONCLUSION: TARE may be a useful downstaging treatment for unresectable localized single large HCC providing comparable short-term and long-term outcomes with readily resectable tumors.
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Authors | Stylianos Tzedakis, Amine Sebai, Heithem Jeddou, Etienne Garin, Yan Rolland, Heloise Bourien, Thomas Uguen, Laurent Sulpice, Fabien Robin, Julien Edeline, Karim Boudjema |
Journal | Annals of surgery
(Ann Surg)
Vol. 278
Issue 5
Pg. 756-762
(11 01 2023)
ISSN: 1528-1140 [Electronic] United States |
PMID | 37539588
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Yttrium-90
- Yttrium Radioisotopes
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Topics |
- Humans
- Carcinoma, Hepatocellular
(radiotherapy, surgery)
- Liver Neoplasms
(radiotherapy, surgery)
- Retrospective Studies
- Yttrium Radioisotopes
(therapeutic use)
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