Abstract |
This paper aimed to investigate the influence of polymorphisms in the FCGR2A gene encoding R131H FcgRIIA variants and in the FCGR3B gene (108G > C, 114C > T, 194 A > G, 233C > A, 244 G > A and 316G > A) encoding FcgRIIIB-NA1, -NA2 and -SH variants on malaria susceptibility and antibody responses against P. falciparum merozoite antigens in Beninese children. An active malaria follow-up was conducted in infants from birth to 24 months of age in Allada, Benin. FCGR3B exon 3 was sequenced and FCGR2A exon 4 was genotyped. Antibodies directed to GLURP and MSP3 were quantified by ELISA. Association studies were performed using mixed-effect models. Individual carriage of FCGR3B 194 AA genotype was associated with a high number of malaria infections and a low level of IgG1 against MSP3 and GLURP-R0. High parasitemia and increased malaria infections were observed in infants carrying the FCGR3B*05 108C-114T-194A-233C-244A-316A haplotype. A reduced risk of malaria infections and low parasitemia were related to the carriages of the FCGR3B 108C-114T-194G-233C-244G-316A (FCGR3B*06), FCGR3B 108C−114T−194G−233A−244A−316A (FCGR3B*03 encoding for FcgRIIIB-SH) haplotypes and FCGR3B 297 TT genotype. Our results highlight the impact of FCGR3B polymorphisms on the individual susceptibility to malaria and antibody responses against MSP3 and GLURP in Beninese children.
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Authors | Abdou Khadre Dit Jadir Fall, David Courtin, Rafiou Adamou, Sofie Edslev, Anita Hansen, Nadia Domingo, Michael Christiansen, Bright Adu, Jacqueline Milet, André Garcia, Michael Theisen, Florence Migot-Nabias, Célia Dechavanne |
Journal | International journal of molecular sciences
(Int J Mol Sci)
Vol. 23
Issue 23
(Nov 28 2022)
ISSN: 1422-0067 [Electronic] Switzerland |
PMID | 36499205
(Publication Type: Journal Article)
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Chemical References |
- Receptors, IgG
- Antigens, Protozoan
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Topics |
- Infant
- Child
- Animals
- Humans
- Merozoites
- Receptors, IgG
(genetics)
- Malaria, Falciparum
(genetics)
- Malaria
(genetics)
- Polymorphism, Genetic
- Antigens, Protozoan
(genetics)
- Plasmodium falciparum
(genetics)
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